Adjuvant targeted therapy for non-small cell lung cancer

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  • Authors: Laktionov K.K.1,2, Kazakov A.M.1, Gordiev M.G.3, Kononets P.V.1, Akhmedov B.B.1, Maevskaia J.N.1,4
  • Affiliations:
    1. Blokhin National Medical Research Center of Oncology
    2. Pirogov Russian National Research Medical University
    3. National BioService
    4. Sechenov First Moscow State Medical University (Sechenov University)
  • Issue: Vol 22, No 2 (2020)
  • Pages: 104-107
  • Section: Review
  • URL: https://modernonco.orscience.ru/1815-1434/article/view/34961
  • Cite item

Abstract


Non-small cell lung cancer (NSCLC) is a heterogeneous group of diseases with a wide range of possible targeted activating mutations. In this regard, a lot of attention is paid to such treatment of patients with NSCLC as adjuvant targeted therapy after radical surgical treatment, nowadays. The active interest in this option is associated with several reasons: sufficient low efficacy of adjuvant chemotherapy, increased capabilities of molecular genetic methods to determine the activating mutations, extensive introduction of liquid biopsy into the clinical practice, as well as the results of the trials associated with the use of targeted therapy both in the treatment of advanced forms of NSCLC and in an adjuvant regimen. The results of such trials as SELECT, ADJUVANT/CTONG1104, ADAURA have shown the benefit of adjuvant targeted therapy in comparison with chemotherapy, placebo or historical control. The ability to identify circulating tumor DNA as a marker of minimal residual disease after surgical treatment, as well as the determination of the mutation profile using the minimally invasive method such as the fluid biopsy will allow achieving an even more personalized approach to the appointment of adjuvant therapy. All this makes the use of adjuvant targeted therapy a promising and effective treatment option.


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About the authors

Konstantin K. Laktionov

Blokhin National Medical Research Center of Oncology; Pirogov Russian National Research Medical University

Author for correspondence.
Email: lkoskos@mail.ru

Russian Federation, Moscow

D. Sci. (Med.), Prof.

Aleksei M. Kazakov

Blokhin National Medical Research Center of Oncology

Email: kazakovich873@gmail.com

Russian Federation, Moscow

Clinical Resident

Marat G. Gordiev

National BioService

Email: kazakovich873@gmail.com

Russian Federation, Saint Petersburg

Dir.

Pavel V. Kononets

Blokhin National Medical Research Center of Oncology

Email: info@ronc.ru

Russian Federation, Moscow

Cand. Sci. (Med.)

Bakhrom B. Akhmedov

Blokhin National Medical Research Center of Oncology

Email: info@ronc.ru

Russian Federation, Moscow

Cand. Sci. (Med.), Senior Res. Officer

Julia N. Maevskaia

Blokhin National Medical Research Center of Oncology; Sechenov First Moscow State Medical University (Sechenov University)

Email: maeva-julia@inbox.ru

Russian Federation, Moscow

Graduate Student

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