Virus-associated pharynx tumors in a 16-year-old boy: the description of the clinical case

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Objectives. The relationship between the development of the number of malignant tumors in children and viruses is well known. The etiological role of the Epstein–Barr virus in the development of undifferentiated nasopharyngeal cancer (NPC) has been well studied. The effect of human papillomavirus (HPV) on the occurrence and development of NPC in children is not sufficiently understood.

Aim. The description of the clinical case of the Epstein Barr virus and HPV infection in 16-year-old patient with the consistent development of NPC and oropharyngeal papillomatosis.

Description of the clinical case. The clinical observation of the boy who was diagnosed with NPC. The full clinical effect in the form of reduction of the primary tumor and metastases in the lymph nodes of the neck was noted after chemo- and radiotherapy. 18 months after the cure according to the positron emission tomography, combined with computed tomography, with 18F-deoxyglucose we marked the accumulation of radiopharmaceuticals in the area of the left palatine and lingual tonsils. The examination revealed clinical signs of the soft palate papillomatosis. The resection of the soft palate was carried out. The morphological study confirmed squamous cell papilloma. HPV type 16 DNA was found in the papilloma.

Conclusion. The accumulation of the information concerning childhood pharynx lesions caused by HPV would help to expand understanding of the most common types of the virus in the paediatric population. It would be possible to identify the groups of risk for the development of malignant tumors on the grounds of the detection HPV types of highly carcinogenic risk.

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About the authors

Tatiana V. Gorbunova

Blokhin National Medical Research Center of Oncology

Author for correspondence.
ORCID iD: 0000-0001-5805-726X

Russian Federation, Moscow

Cand. Sci. (Med.)

Elena Iu. Radtsig

Pirogov Russian National Research Medical University

ORCID iD: 0000-0003-4613-922X

Russian Federation, Moscow

D. Sci. (Med.), Prof.

Oleg A. Merkulov

Blokhin National Medical Research Center of Oncology

ORCID iD: 0000-0002-8533-0724

Russian Federation, Moscow

Cand. Sci. (Med.)

Mikhail R. Bogomil’skii

Pirogov Russian National Research Medical University


Russian Federation, Moscow

D. Sci. (Med.), Prof., Acad. RAS

Vladimir G. Poliakov

Blokhin National Medical Research Center of Oncology

ORCID iD: 0000-0002-8096-0874

Russian Federation, Moscow

D. Sci. (Med.), Prof., Acad. RAS


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Supplementary files

Supplementary Files Action
Fig. 1: a – the arrow shows pathological tissues in the nasopharynx, blocking the lumen, involving the palatine tonsils, heterogeneous accumulating contrast drug; b – the arrow shows almost complete narrowing of the nasopharynx lumen.

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Fig. 2. The arrow indicates the tumor that occupies the nasopharynx and prolapses into the choana.

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Fig. 3: a – the arrow shows the nasopharyngeal vault with the presence of indecipherable additional tissues; b – the arrow shows the clear lumen of the nasopharynx.

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Fig. 4. Multiple papillomas of the soft palate.

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