Inhibin B in diagnosis and monitoring of granulosa-cell tumors of ovary

Cover Page

Abstract


Introduction. Granulosa cell tumors of ovary (GCTO) – rare type of malignant ovarian neoplasms formed from granulosa cells of the follicles capable to produce biologically active substances, including inhibin B. The purpose of this study is evaluation of clinical significance of inhibin B analysis in blood serum of patients with adult type of GCTO primary disease, relapse and during remission after treatment.

Materials and methods. The study included 134 patients with GCTO, 15 patients with benign ovarian tumors and 82 healthy women. Inhibin B was determined in blood serum with standard enzyme-linked immunosorbent assay Inhibin B Gen II ELISA (Beckman Coulter, USA) in the microplate format.

Results. The analysis data indicates a high sensitivity of inhibin B in the diagnosis of primary GCTO (92.3%) and in relapse (92.7%) with a specificity 100%. An increase of inhibin B before the clinical manifestation of relapse (for 2–12 months) confirms its significance as an effective biochemical marker for GCTO monitoring.

Conclusion. Inhibin B can be used as effective biochemical marker of primary and GCTO and its relapses.


Full Text

Restricted Access

About the authors

Nina V. Lyubimova

Blokhin National Medical Research Centre of Oncology

Author for correspondence.
Email: biochimia@yandex.ru
ORCID iD: 0000-0003-0430-2754

Russian Federation, Moscow

D. Sci. (Biol.), Prof.

Almaz M. Beishembaev

Daniyarov Kyrgyz State Medical Institute of Re-education and Preferment Qualification

Email: biochimia@yandex.ru

Kyrgyzstan, Bishkek

Cand. Sci. (Med.)

Yurii S. Timofeev

Blokhin National Medical Research Centre of Oncology

Email: biochimia@yandex.ru

Russian Federation, Moscow

Cand. Sci. (Med.)

Kirill I. Zhordania

Blokhin National Medical Research Centre of Oncology

Email: biochimia@yandex.ru

Russian Federation, Moscow

D. Sci. (Med.), Prof.

Nikolai E. Kushlinskii

Blokhin National Medical Research Centre of Oncology

Email: biochimia@yandex.ru
ORCID iD: 0000-0002-3898-4127

Russian Federation, Moscow

D. Sci. (Med.), Prof., Acad. RAS

References

  1. Bryk S, Färkkilä A, Bützow R et al. Clinical characteristics and survival of patients with an adult-type ovarian granulosa cell tumor: a 56-year single-center experience. Int J Gynecol Cancer 2015; 25 (1): 33–41.
  2. Mancari R, Portuesi R, Colombo N. Adult granulosa cell tumours of the ovary. Curr Opin Oncol 2014; 26: 536–41.
  3. Färkkilä A, Haltia UM, Tapper J et al. Pathogenesis and treatment of adult-type granulosa cell tumor of the ovary. Ann Med 2017; 49 (5): 435–47.
  4. Agha-Hosseini M, Aleyaseen A, Safdarian L, Kashani L. Secondary amenorrhea with low serum luteinizing hormone and follicle-stimulating hormone caused by an inhibin A- and inhibin B-producing granulosa cell tumor. Taiwan J Obstet Gynecol 2009; 48 (1): 72–5.
  5. Burger HG, Fuller PJ, Chu S et al. The inhibins and ovarian cancer. Mol Cell Endocrinol 2001; 180 (1–2): 145–8.
  6. Robertson DM, Stephenson T, Pruysers E et al. Inhibins/activins as diagnostic markers for ovarian cancer. Mol Cell Endocrinol 2002; 191 (1): 97–103.
  7. Geerts I, Vergote I, Neven P, Billen J. The role of inhibins B and antimüllerian hormone for diagnosis and follow-up of granulosa cell tumors. Int J Gynecol Cancer 2009; 19 (5): 847–55.
  8. Groome NP, Illingworth PJ, O’Brien M et al. Measurement of dimeric inhibin B throughout the human menstrual cycle. J Clin Endocrinol Metab 1996; 81 (4): 1401–5.
  9. Бейшембаев А.М., Любимова Н.В., Кушлинский Д.Н. и др. Гранулезоклеточные опухоли яичников и ингибин В. Бюл. эксперимен. биологии и медицины. 2010; 150 (11): 567–70. [Beishembaev A.M., Liubimova N.V., Kushlinskii D.N. et al. Granulezokletochnye opukholi iaichnikov i ingibin V. Biul. eksperimen. biologii i meditsiny. 2010; 150 (11): 567–70 (in Russian).]
  10. Жорданиа К.И., Кержковская Н.С., Паяниди Ю.Г. и др. Гранулезоклеточные опухоли яичника. Диагностика и лечение. Онкогинекология. 2014; 2: 33–41. [Zhordania K.I., Kerzhkovskaia N.S., Paianidi Iu.G. et al. Granulezokletochnye opukholi iaichnika. Diagnostika i lechenie. Onkoginekologiia. 2014; 2: 33–41 (in Russian).]
  11. Haltia UM, Hallamaa M, Tapper J et al. Roles of human epididymis protein 4, carbohydrate antigen 125, inhibin B and anti-Müllerian hormone in the differential diagnosis and follow-up of ovarian granulosa cell tumors. Gynecol Oncol 2017; 144 (1): 83–9.
  12. Mom CH, Engelen MJ, Willemse PH. Granulosa cell tumors of the ovary: the clinical value of serum inhibin A and B levels in a large single center. Gynecol Oncol 2007; 105: 365–72.
  13. Burger HG. Caracterization of inhibin immunoreactivity in post-menopausal women with ovarian tumors. Clin Endocrino 1996; 44: 413–8.
  14. Mangili G, Ottolina J, Gadducci A et al. Long-term follow-up is crucial after treatment for granulosa cell tumours of the ovary. Br J Cancer 2013; 109 (1): 29–34.
  15. Kurihara S, Hirakawa T, Amada S et al. Inhibin-producing ovarian granulosa cell tumor as a cause of secondary amenorrhea: case report and review of the literature. J Obstet Gynaecol Res 2004; 30 (6): 439–43.

Statistics

Views

Abstract - 24

PDF (Russian) - 1

Cited-By


PlumX

Dimensions

Refbacks

  • There are currently no refbacks.


Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies