Patterns of changes in certain neurospecific proteins in patients with post-contact period chronic mercury intoxication

封面

如何引用文章

全文:

开放存取 开放存取
受限制的访问 ##reader.subscriptionAccessGranted##
受限制的访问 订阅存取

详细

The aim of the study was to identify patterns of change in certain neurospecific proteins (BDNF, S100β, MBP) in the serum of patients with chronic mercury intoxication (CMI) after stopping exposure to the toxicant. In clinical conditions, men with an established diagnosis of chronic mercury intoxication were examined in a distant period after isolation from a toxicant in chemical production. Serum concentrations of neurospecific proteins (BDNF, S100β, MBP) were determined by solid-phase enzyme-linked immunosorbent assay using a commercial test-systems of ChemiKine (USA), CanAg (Sweden) and AnshLabs (США) respectively. The obtained results indicate and confirm the progressionality of the disease process in the distant, post-exposure period of chronic mercury intoxication, which corresponds to the clinic of the manifestation of the disease. Elevated serum concentrations of BDNF, S100β protein, and MBP were reported in patients with CMI after 5 years of exposure to the toxicant. Long-lasting high levels of neurotrophic proteins may reflect the course of neurodestructive processes occurring in the nervous tissue and the progression of the disease. BDNF deficiency in CMI individuals examined in a linked sample at 8 years post-exposure may be indicative of attenuation of neurogenesis. Further studies will contribute to a more accurate definition and understanding of the use of serum concentrations of BDNF, S100β protein, MBP as markers of pathological process activity and a specific target for effective treatment.

全文:

受限制的访问

作者简介

G. Bodienkova

Scientific Institution “East-Siberian Institute of Medical and Ecological Research”

编辑信件的主要联系方式.
Email: immun11@yandex.ru
俄罗斯联邦, Angarsk

E. Boklazhenko

Scientific Institution “East-Siberian Institute of Medical and Ecological Research”

Email: immun11@yandex.ru
俄罗斯联邦, Angarsk

参考

  1. Лахман О.Л., Рукавишников В.С., Шаяхметов С.Ф., Соседова Л.М., Катаманова Е.В., Бодиенкова Г.М., Кудаева И.В., Шевченко О.И., Русанова Д.В., Журба О.М. // Медицина труда и промышленная экология. 2015. № 9. С. 82–83.
  2. Астахин А.В., Евлашева О.О., Левитан Б.Н. // Астраханский медицинский журнал. 2015. Т. 10. № 2. С. 42–46.
  3. Левчук Л.А., Вялова Н.М., Михалицкая Е.В., Семкина А.А., Иванова С.А. // Современные проблемы науки и образования. 2018. № 6. С. 58.
  4. Бодиенкова Г.М., Курчевенко С.И. // Медицина труда и промышленная экология. 2014. № 4. С. 34–37.
  5. Lopresti A.L., Maker G.L., Hood S.D., Drummond P.D. // Prog. Neuropsychopharmacol Biol. Psychiatry. 2014. V. 48. P. 102–111. https://doi.org/10.1016/j.pnpbp.2013.09.017
  6. Woolf C.J., Salter M.W. // Science. 2000. V. 288. № 5472. P. 1765–1768. https://doi.org/10.1126/science.288.5472.1765
  7. Colucci-D’Amato L., Speranza L., Volpicelli F. // Int. J. Mol. Sci. 2020. V. 21. № 20. P. 7777. https://doi.org/10.3390/ijms21207777
  8. Dwivedi Y. // Neuropsychiatric Disease and Treatment. 2009. V. 5. P. 433–449. https://doi.org/10.2147/ndt.s5700
  9. Ермаков С.В., Можейко Р.А., Батурин В.А., Белоконь О.С. // Вестник современной клинической медицины. 2018. Т. 11. № 6. С. 11–15.
  10. Астахин А.В., Евлашева О.О., Левитан Б.Н. // Астраханский медицинский журнал. 2016. Т. 11. № 4. С. 9–17.
  11. Усманова Д., Маджидова Ё.Н. // Сибирское медицинское обозрение. 2017. № 1(103). С. 60–63. https://doi.org/10.20333/2500136-2017-1-60-63
  12. Kytikova O. Yu., Novgorodtseva T.P., Antonyuk M.V., Gvozdenko T.A. // Bulletin of Siberian Medicine. 2021. V. 20. № 1. P. 158–167. https://doi.org/10.20538/1682-0363-2021-1-158-167
  13. Бодиенкова Г.М., Боклаженко Е.В. // Нейрохимия. 2021. Т. 38. № 4. С. 385–390. https://doi.org/10.31857/S1027813321040026
  14. Липатова Л.В., Серебрянная Н.Б., Капустина Т.В., Сивакова Н.А. // Аллергология и иммунология. 2017. Т. 18. № 1. С. 60.
  15. Бодиенкова Г.М., Боклаженко Е.В. // Успехи современного естествознания. 2015. № 5. С. 105–108.
  16. Бодиенкова Г.М., Боклаженко Е.В. // Бюллетень ВСНЦ СО РАМН. 2011. № 3–2 (79). С. 140–143.
  17. Григорьян Г.А., Дыгало Н.Н., Гехт А.Б., Степаничев М.Ю., Гуляева Н.В. // Успехи физиологических наук. 2014. Т. 45. № 2. С. 3–19.
  18. Боклаженко Е.В., Бодиенкова Г.М. // Бюллетень ВСНЦ СО РАМН. 2010. № 1 (71). С. 14–16.
  19. Боклаженко Е.В., Бодиенкова Г.М., Русанова Д.В. // Медицинская иммунология. 2019. Т. 21. № 6. С. 1197–1202. doi: 10.15789/1563-0625-2019-6-1197-1202.

补充文件

附件文件
动作
1. JATS XML

版权所有 © Russian Academy of Sciences, 2024