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Anxious and melancholic depression are followed by differently directed serum albumin conformation
- Authors: Uzbekov M.G.1, Smolina N.V.1, Syrejshchikova T.I.1, Maximova N.M.1, Shikhov S.N.1, Dobretsov G.E.1, Brilliantova V.V.1, Krjukov V.V.1
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Affiliations:
- Moscow Research Institute of Psychiatry
- Issue: Vol 41, No 1 (2024)
- Pages: 14-18
- Section: Clinical Neurochemistry
- URL: https://modernonco.orscience.ru/1027-8133/article/view/653910
- DOI: https://doi.org/10.31857/S1027813324010022
- EDN: https://elibrary.ru/GZHVIJ
- ID: 653910
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Abstract
The aim of the study was investigation of the peculiarities of the conformational changes of serum albumin in patients with anxious and melancholic depression. Albumin conformation was measured by the method of the subnanosecond laser time resolved fluorescence spectroscopy. Anxious depression was followed with the significant decrease of the values of the three amplitudes on the serum albumin in comparison with controls. In the melancholic depression the values of all three amplitudes on serum albumin molecules were significantly elevated in comparison with controls. These results are clearly indicated that anxious and melancholic depression are followed by differently directed changes in serum albumin conformation.
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About the authors
M. G. Uzbekov
Moscow Research Institute of Psychiatry
Author for correspondence.
Email: uzbekovmg@gmail.com
Russian Federation, Moscow
N. V. Smolina
Moscow Research Institute of Psychiatry
Email: uzbekovmg@gmail.com
Russian Federation, Moscow
T. I. Syrejshchikova
Moscow Research Institute of Psychiatry
Email: uzbekovmg@gmail.com
Russian Federation, Moscow
N. M. Maximova
Moscow Research Institute of Psychiatry
Email: uzbekovmg@gmail.com
Russian Federation, Moscow
S. N. Shikhov
Moscow Research Institute of Psychiatry
Email: uzbekovmg@gmail.com
Russian Federation, Moscow
G. E. Dobretsov
Moscow Research Institute of Psychiatry
Email: uzbekovmg@gmail.com
Russian Federation, Moscow
V. V. Brilliantova
Moscow Research Institute of Psychiatry
Email: uzbekovmg@gmail.com
Russian Federation, Moscow
V. V. Krjukov
Moscow Research Institute of Psychiatry
Email: uzbekovmg@gmail.com
Russian Federation, Moscow
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