The Study of the Influence of Pyridine Oxime Derivative (GIZh-298) And Sodium Valproate on the Neurotransmitter Amino Acids Content in the Brain Structures of Mice in the Maximal Electroconvulsive Seizures Test

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Abstract

The effect of the antiepileptic compound GIZH-298 and the reference drug sodium valproate (VN) on the content of excitatory and inhibitory amino acids in the frontal cortex, hypothalamus, striatum, and hippocampus of the brain of mice after an electric shock-induced generalized tonic-clonic seizure (MES) was studied. It has been shown that the application of MES reduces the levels of aspartate, glycine, GABA and the ratio of “GABA/glutamate” in the hypothalamus. In the latter, a decrease in the concentration of glutamate, glycine and taurine was noted. VN (200 mg/kg/g) counteracts the effects of MES by interfering with the resulting decrease in GABA and the GABA/glutamate ratio in the hypothalamus. In the hypothalamus, striatum, and hippocampus, VN causes a decrease in the aspartate content both in intact control groups and in the group of mice that received MES. GIZH-298 (60 mg/kg/int. gastric) prevented the MES-induced decrease in the levels of GABA, glycine and taurine and the GABA/glutamate ratio in the hypothalamus.

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V. B. Narkevich

Federal Research Center for Original and Prospective Biomedical and Pharmaceutical Technologies

Author for correspondence.
Email: narvik@yandex.ru
Russian Federation, Moscow

S. A. Litvinova

Federal Research Center for Original and Prospective Biomedical and Pharmaceutical Technologies

Email: narvik@yandex.ru
Russian Federation, Moscow

K. A. Kasabov

Federal Research Center for Original and Prospective Biomedical and Pharmaceutical Technologies; I.M. Sechenov First Moscow state medical University (Sechenov University)

Email: narvik@yandex.ru
Russian Federation, Moscow; Moscow

A. A. Yakovleva

Federal Research Center for Original and Prospective Biomedical and Pharmaceutical Technologies

Email: narvik@yandex.ru
Russian Federation, Moscow

V. S. Kudrin

Federal Research Center for Original and Prospective Biomedical and Pharmaceutical Technologies

Email: narvik@yandex.ru
Russian Federation, Moscow

T. A. Voronina

Federal Research Center for Original and Prospective Biomedical and Pharmaceutical Technologies

Email: narvik@yandex.ru
Russian Federation, Moscow

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