The Peculiarities of Neutrophils Migration Processes in the Flow System

Мұқаба

Дәйексөз келтіру

Толық мәтін

Аннотация

A flow system model simulating the hemodynamic process in capillaries was created to study neutrophil migration. It was found that the general patterns of neutrophil behavior (aggregate formation, formation of neutrophil tethers and migration of neutrophils along intercellular contacts of endothelial cells) are reproduced both in the control (system without chemoattractants) and in the experiment (system with low-molecular chemoattractants of bacteria), however, in the case of S. aureus and P. mirabilis using as a chemoattractant, the number of aggregates and neutrophil tethers increases statistically significantly (p < 0.05). Aggregates correspond to the swarming phenomenon in the transendothelial migration system and help limit the zone of bacterial damage. And neutrophil tethers cause a stop in hemodynamic movement and can cause either a transition to migration or be precursors to the formation of elongated neutrophil-derived structures with high antibacterial potential. Thus, all the observed phenomena contribute to the implementation of the protective function in case of bacteremia.

Авторлар туралы

S. Pleskova

Lobachevsky Nizhny Novgorod State University; Nizhny Novgorod State Technical University named after R.E. Alekseev

Email: pleskova@mail.ru
Nizhny Novgorod, Russia; Nizhny Novgorod, Russia

N. Bezrukov

Lobachevsky Nizhny Novgorod State University

Nizhny Novgorod, Russia

E. Gorshkova

Lobachevsky Nizhny Novgorod State University

Nizhny Novgorod, Russia

D. Novikov

Lobachevsky Nizhny Novgorod State University; Nizhny Novgorod Research Institute of Epidemiology and Microbiology named after Academician I.N. Blokhina

Nizhny Novgorod, Russia; Nizhny Novgorod, Russia

E. Otstavnova

Lobachevsky Nizhny Novgorod State University; Nizhny Novgorod State Technical University named after R.E. Alekseev

Nizhny Novgorod, Russia; Nizhny Novgorod, Russia

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