Hypothermia and Reproductive Function of Male Mammals

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Abstract

The human and animal reproductive systems are sensitive to temperature, but there are very few studies on the effects of hypothermia. The widespread application of therapeutic hypothermia requires a comprehensive study of the time-delayed effects of low temperature on a variety of physiological systems. Hibernating mammals have a significant potential for reactivation of the reproductive system after prolonged hypothermia and can serve as an important experimental model for the development of new methods of treatment and prevention of human reproductive diseases. This review presents an analysis of currently available data on disorders in the mammalian reproductive system under hypothermia, and also discusses the mechanisms of natural protection of reproductive function in hibernating mammals.

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About the authors

E. V. Kuznetsova

Avtsyn Research Institute of Human Morphology

Author for correspondence.
Email: kuznetsovaekvl@gmail.com
Russian Federation, Moscow

N. B. Tikhonova

Avtsyn Research Institute of Human Morphology

Email: kuznetsovaekvl@gmail.com
Russian Federation, Moscow

E. A. Ponomarenko

Avtsyn Research Institute of Human Morphology

Email: kuznetsovaekvl@gmail.com
Russian Federation, Moscow

V. A. Kuznetsov

Sechenov First Moscow State Medical University

Email: kuznetsovaekvl@gmail.com
Russian Federation, Moscow

N. V. Nizyaeva

Avtsyn Research Institute of Human Morphology

Email: kuznetsovaekvl@gmail.com
Russian Federation, Moscow

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2. Fig. 1. Scheme of body temperature changes in an obligate hibernator; 1 - period of hypothermia; 2 - inter-boute awakening. Yellow colour indicates the period of activity with maintenance of euthermia, blue - heterothermic period (hibernation). The figure is based on the data of the authors of the present work [51].

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3. Fig. 2. Effects of hypothermia on the reproductive system of males of hibernating and non-hibernating mammalian species, as well as mechanisms of adaptation of spermatogenesis to hypothermia realised in hibernating animals.

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