Zebrafish аs а Promising Experimental Model of Traumatic Brain Injury

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Traumatic brain injury (TBI) involves various types of physical injuries to brain tissue. TBI is a highly heterogeneous clinical condition, whose symptoms include cognitive, motor and emotional deficits, as well as neurodegeneration and neuroinflammation. Animal modeling plays a key role in studying TBI, expanding our knowledge of TBI and its temporal dynamics, and to develop new drugs for its treatment. Recently, the use of the bony zebrafish (Danio rerio) as an aquatic model organism has attracted particular interest in translational neurobiology. Zebrafish are presently second (after mice) laboratory animal species most used in biomedicine. Here, we discuss the prospects of using zebrafish to model TBI, as well as problems and new directions of research in this area. We also emphasize the importance of zebrafish as a highly translational model for studying the molecular mechanisms and neurological disorders in TBI, as well as screening for potential therapeutic agents.

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作者简介

A. Shevlyakov

World-class Scientific Center “Center for Personalized Medicine”, Almazov National Medical Research Center, Ministry of Healthcare; Scientific Center for Genetics and Life Sciences, Sirius University of Science and Technology

Email: avkalueff@gmail.com

Neurobiology Program and Immunobiology and Biomedicine Program

俄罗斯联邦, St. Petersburg; Federal Territory Sirius

N. Ilyin

World-class Scientific Center “Center for Personalized Medicine”, Almazov National Medical Research Center, Ministry of Healthcare; Institute of Translational Biomedicine, St. Petersburg State University

Email: avkalueff@gmail.com
俄罗斯联邦, St. Petersburg; St. Petersburg

D. Galstyan

World-class Scientific Center “Center for Personalized Medicine”, Almazov National Medical Research Center, Ministry of Healthcare; Institute of Translational Biomedicine, St. Petersburg State University; Institute of Experimental Medicine, Almazov National Medical Research Center, Ministry of Healthcare

Email: avkalueff@gmail.com
俄罗斯联邦, St. Petersburg; St. Petersburg; St. Petersburg

A. Ikrin

Neurobiology Program and Immunobiology and Biomedicine Program, Scientific Center for Genetics and Life Sciences, Sirius University of Science and Technology

Email: avkalueff@gmail.com

Neurobiology Program and Immunobiology and Biomedicine Program

俄罗斯联邦, Federal Territory Sirius

T. Kolesnikova

Neurobiology Program and Immunobiology and Biomedicine Program, Scientific Center for Genetics and Life Sciences, Sirius University of Science and Technology

Email: avkalueff@gmail.com

Neurobiology Program and Immunobiology and Biomedicine Program

俄罗斯联邦, Federal Territory Sirius

K. Apukhtin

Neurobiology Program and Immunobiology and Biomedicine Program, Scientific Center for Genetics and Life Sciences, Sirius University of Science and Technology

Email: avkalueff@gmail.com

Neurobiology Program and Immunobiology and Biomedicine Program

俄罗斯联邦, Federal Territory Sirius

M. Kotova

Neurobiology Program and Immunobiology and Biomedicine Program, Scientific Center for Genetics and Life Sciences, Sirius University of Science and Technology

Email: avkalueff@gmail.com

Neurobiology Program and Immunobiology and Biomedicine Program

俄罗斯联邦, Federal Territory Sirius

V. Nikitin

Neurobiology Program and Immunobiology and Biomedicine Program, Scientific Center for Genetics and Life Sciences, Sirius University of Science and Technology

Email: avkalueff@gmail.com

Neurobiology Program and Immunobiology and Biomedicine Program

俄罗斯联邦, Federal Territory Sirius

T. Amstislavskaya

Research Institute of Neuroscience and Medicine

Email: avkalueff@gmail.com
俄罗斯联邦, Novosibirsk

E. Petersen

Moscow Institute of Physics and Technology

Email: avkalueff@gmail.com

Laboratory of Molecular Biological and Neurobiological Problems and Bioscreening

俄罗斯联邦, Dolgoprudny

A. Kalueff

World-class Scientific Center “Center for Personalized Medicine”, Almazov National Medical Research Center, Ministry of Healthcare; Scientific Center for Genetics and Life Sciences, Sirius University of Science and Technology; Institute of Translational Biomedicine, St. Petersburg State University; Institute of Experimental Medicine, Almazov National Medical Research Center, Ministry of Healthcare; Research Institute of Neuroscience and Medicine

编辑信件的主要联系方式.
Email: avkalueff@gmail.com

Neurobiology Program and Immunobiology and Biomedicine Program

俄罗斯联邦, St. Petersburg; Federal Territory Sirius; St. Petersburg; St. Petersburg; Novosibirsk

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2. Fig. 1. The generally accepted classification of traumatic brain injury (TBI).

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3. Fig. 2. Molecular dysfunctions in traumatic brain injury.

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4. Fig. 3. The role of microglia and astrocytes in the process of neuroinflammation in traumatic brain injury. M1, M2 are microglia, A1, A2 are astrocytes.

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5. Fig. 4. Approximate temporal dynamics of cell death phases in neurotrauma (TBI) in zebrafish. The red and blue lines indicate the primary and secondary responses (measured in the level of NeuN expression). The green dotted line indicates a compensatory response (measured in the level of BDNF expression). On the Y–axis, the % of the response from the norm (taken as 100%) is postponed, on the X-axis is the time (days) after TBI (red arrow).

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6. Fig. 5. General setup (left) for laser induction of neurotrauma in adult zebrafish (right) [62].

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