Method of synthesis of 4-substituted 3-nitrophenyl carbonyls from benzyl alcohols

Daniil A. Kazantsev; Казанцев Д. А.; Alexander A. Denisov; Денисов А. А.; Alexander V. Pestov; Пестов А. В.

doi:10.31857/S0514749224120047

Method of synthesis of 4-substituted 3-nitrophenyl carbonyls from benzyl alcohols

Authors: Kazantsev D.A.¹, Denisov A.A.¹^,2, Pestov A.V.¹^,2
Affiliations:
1. I.Ya. Postovsky Insititute of Organic Synthesis of the Ural Branch of the Russian Academy of Sciences
2. Ural Federal University
Issue: Vol 60, No 12 (2024)
Pages: 1209-1215
Section: Articles
URL: https://modernonco.orscience.ru/0514-7492/article/view/681813
DOI: https://doi.org/10.31857/S0514749224120047
EDN: https://elibrary.ru/AQMXWT
ID: 681813

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Abstract
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Abstract

A method has been developed for the production of 4-substituted-3-nitrophenyl carbonyl s based on the tandem oxidation and nitration process of benzyl alcohols. The proposed method is single-reactor and makes it possible to obtain target compounds with good yield, under mild conditions, using stable commercially available starting substances.

Keywords

nitrooxidation, tandem process, 4-chloro-3-nitrobenzaldehyde, 4-bromo-3-nitrobenzaldehyde, 4-methyl-3-nitrobenzaldehyde, (4-methyl-3-nitrophenyl)phenylketon

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About the authors

Daniil A. Kazantsev

I.Ya. Postovsky Insititute of Organic Synthesis of the Ural Branch of the Russian Academy of Sciences

Author for correspondence.
Email: daniil_kazantsev@mail.ru
ORCID iD: 0009-0008-8648-3395
Russian Federation, Sofya Kovalevskaya st., 22/20, Yekaterinburg, 620108

Alexander A. Denisov

I.Ya. Postovsky Insititute of Organic Synthesis of the Ural Branch of the Russian Academy of Sciences; Ural Federal University

Email: daniil_kazantsev@mail.ru
ORCID iD: 0009-0000-4715-8284

Ural Federal University, The Institute of Natural Sciences and Mathematics

Russian Federation, Sofya Kovalevskaya st., 22/20, Yekaterinburg, 620108; Kuibysheva st., 48, Yekaterinburg, 620026

Alexander V. Pestov

I.Ya. Postovsky Insititute of Organic Synthesis of the Ural Branch of the Russian Academy of Sciences; Ural Federal University

Email: daniil_kazantsev@mail.ru
ORCID iD: 0000-0002-4270-3041

Ural Federal University, The Institute of Natural Sciences and Mathematics

Russian Federation, Sofya Kovalevskaya st., 22/20, Yekaterinburg, 620108; Kuibysheva st., 48, Yekaterinburg, 620026

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