Recyclization of 5-Aryl-1H-pyrrole-2,3-diones under the Action of Amidoximes. Synthesis of Enamines with a 1,2,4-Oxadiazole Moiety

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Abstract

5-Aryl-1Н-pyrrole-2,3-diones react with amidoximes to form enamines with a 1,2,4-oxadiazole fragment, which are potential precursors of a new type of 1Н-pyrrole-2,3-diones. The described reaction is the first example of the recyclization of 4-unsubstituted 5-aryl-1H-pyrrole-2,3-diones under action of 1,4-binucleophilic reagent.

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About the authors

Dmitry I. Antonov

Perm State University

Author for correspondence.
Email: koh2@psu.ru
ORCID iD: 0000-0002-7101-1351
Russian Federation, 15, Bukirev St., Perm, 614068

Maxim V. Dmitriev

Perm State University

Email: koh2@psu.ru
ORCID iD: 0000-0002-8817-0543
Russian Federation, 15, Bukirev St., Perm, 614068

Ilya A. Kuchumov

Perm State University

Email: koh2@psu.ru
ORCID iD: 0000-0002-4511-7451
Russian Federation, 15, Bukirev St., Perm, 614068

Andrey N. Maslivets

Perm State University

Email: koh2@psu.ru
ORCID iD: 0000-0001-7148-4450
Russian Federation, 15, Bukirev St., Perm, 614068

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2. Scheme

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3. Fig. General view of the molecule of compound 3a from PCA data in the representation of atoms by thermal vibration ellipsoids with 30% probability.

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