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Synthesis and Evaluation of the Neurotropic Activity of New Tetrahydropyridazin-3-one Derivatives
- Authors: Khachikyan R.D.1, Hovakimyan Z.G.1, Panosyan G.A.1, Mirzoyan L.S.1, Paronikyan R.G.1
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Affiliations:
- The Institut of Organic Chemistry of the Scientific Technological Centre of Organic and Pharmaceutical Chemistry of NA S of Republic of Armenia
- Issue: Vol 60, No 11 (2024)
- Pages: 1159-1164
- Section: Articles
- URL: https://modernonco.orscience.ru/0514-7492/article/view/682502
- DOI: https://doi.org/10.31857/S0514749224110103
- EDN: https://elibrary.ru/QHGOZX
- ID: 682502
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Abstract
It was established that 4-aryl-4-oxo-2-indol-3-yl butanoic acid and its derivatives upon interaction with hydrazine form 6-aryl-4-[(unsubstituted and substituted) indol-3-yl]-2, 3, 4, 5-tetrahydropyridazin-3-ones, while similarly constructed 4-aryl-4-oxo-2-heterylbutanoic acids under similar conditions are heterocyclized with subsequent azole elimination, resulting in the formation of 6-aryl-2,3-dihydropyridazin-3-ones. The study of the neurotropic activity of new tetrahydropyridazinones derivatives showed that all of the studied substances have anxiolytic action.
About the authors
R. Dzh. Khachikyan
The Institut of Organic Chemistry of the Scientific Technological Centre of Organic and Pharmaceutical Chemistry of NA S of Republic of Armenia
Email: khachikyanraya@gmail.com
ORCID iD: 0009-0006-2014-7861
Armenia, Azatutyan Ave. 26, Yerevan, 0014
Z. G. Hovakimyan
The Institut of Organic Chemistry of the Scientific Technological Centre of Organic and Pharmaceutical Chemistry of NA S of Republic of Armenia
Email: khachikyanraya@gmail.com
ORCID iD: 0009-0000-1604-5834
Armenia, Azatutyan Ave. 26, Yerevan, 0014
G. A. Panosyan
The Institut of Organic Chemistry of the Scientific Technological Centre of Organic and Pharmaceutical Chemistry of NA S of Republic of Armenia
Email: khachikyanraya@gmail.com
ORCID iD: 0000-0001-8311-6276
Armenia, Azatutyan Ave. 26, Yerevan, 0014
L. S. Mirzoyan
The Institut of Organic Chemistry of the Scientific Technological Centre of Organic and Pharmaceutical Chemistry of NA S of Republic of Armenia
Author for correspondence.
Email: khachikyanraya@gmail.com
ORCID iD: 0009-0003-4915-9805
Armenia, Azatutyan Ave. 26, Yerevan, 0014
R. G. Paronikyan
The Institut of Organic Chemistry of the Scientific Technological Centre of Organic and Pharmaceutical Chemistry of NA S of Republic of Armenia
Email: khachikyanraya@gmail.com
ORCID iD: 0000-0002-3845-6324
Armenia, Azatutyan Ave. 26, Yerevan, 0014
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