Synthesis of 5-Aryl-4-thioxo-2,3,4,5,6,8-hexahydro-7H-pyrido[3,2-e][1,3]thiazine-7-ones

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Abstract

Upon interaction of N-methylmorpholinium 4-aryl-5-cyano-2-oxo-1,2,3,4-tetrahydropyridine-6-thiolates with hydrogen sulfide and formaldehyde in ethanol 5-aryl-4-thioxo-2,3,4,5,6,8-hexahydro-7H-pyrido[3,2-e][1,3]thiazine-7-ones were obtained. The molecular and crystal structures of N-methylmorpholinium 5-cyano-4-(3,4,5-trimethoxyphenyl)-2-oxo-1,2,3,4-tetrahydropyridine-6-thiolate were studied using X-ray diffraction analysis.

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About the authors

К. А. Frolov

V. Dahl Lugansk State University

Author for correspondence.
Email: ksg-group-lugansk@mail.ru
ORCID iD: 0000-0002-8045-7582

Chemex Lab

Russian Federation, kv. Molodyozhny 20-A/7, Lugansk, 291034

B. S. Krivokolysko

V. Dahl Lugansk State University

Email: ksg-group-lugansk@mail.ru
ORCID iD: 0000-0002-3181-7609

Chemex Lab

Russian Federation, kv. Molodyozhny 20-A/7, Lugansk, 291034

V. V. Dotsenko

Kuban State University

Email: ksg-group-lugansk@mail.ru
ORCID iD: 0000-0001-7163-0497
Russian Federation, ul. Stavropolskaya, 149, Krasnodar, 350040

N. A. Aksenov A. Aksenov

North Caucasus Federal University

Email: ksg-group-lugansk@mail.ru
ORCID iD: 0000-0002-7125-9066
Russian Federation, ul. Pushkina, 1-A, Stavropol, 355009

S. G. Krivokolysko

V. Dahl Lugansk State University

Email: ksg-group-lugansk@mail.ru
ORCID iD: 0000-0001-9879-9217

Chemex Lab

Russian Federation, kv. Molodyozhny 20-A/7, Lugansk, 291034

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Supplementary files

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2. Схема 1a - f, 2a-f: Ar = 2-ClC6H4 (a), 4-Meoc6h4 (b), 2-MeC6H4 (c), 2-EtOC6H4 (d), 2,5-(MeO) 2C6H3 (e), 3,4,5-(MeO)3C6H2 (f)

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3. Table

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4. Formulas

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5. Fig. Atomic and molecular structure of compound 1f. Thermal ellipsoids of non-hydrogen atoms are shown at a 50% probability of finding an atom.

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