Breast cancer incidence rates in women exposed to occupational ionizing radiation

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Abstract

Introduction. Breast cancer (BC) is one of the most common malignancies within female incidence and mortality patterns in the RF. 

Study objective. To analyze BC incidence in females exposed to occupational ionizing radiation over prolonged periods. 

Materials and methods. The study cohort included 5689 females who had been occupationally exposed to ionizing radiation throughout 1948–1982 and followed up until 31.12.2018. 

Results. BC was on the top of the list among females of the study cohort (11.9%). BC prevalence rate in the female cohort understudy was 28.3% as of 31.12.2018. The standardized BrCa incidence rate was 0.88 ± 0.07 per 1000 person-years of the follow-up. The absolute BrCa case increase in the females was 1.29, with the rise of 232.48% by the end of the follow-up due to the rise in age categories of females and the elevating risk of the disease occurrence.

Discussion. The study cohort of females demonstrated standardized BrCa incidence rates consistent with the corresponding estimates for the general female population of the RF. Meanwhile, the observed rates were lower than those estimated for the female population of the Chelyabinsk region. The increasing trend of the standardized BC incidence rate by the end of the follow-up period (31.12.2018) was consistent with WHO statistics. The extended follow-up for an updated assessment of ionizing radiation effect on BC incidence is required to develop new cancer prevention strategies.

Conclusion. The study demonstrated that BC incidence rates in the study cohort varied by age and calendar period of the follow-up. The increasing trend of the standardized rates of BC incidence was observed by the end of the follow-up.

Contribution of the authors:

Rumyantseva A.V. — the concept and design of the study, the collection and processing of the material, writing a text, editing;

Azizova T.V. — the concept and design of the study, writing a text, editing;

Zubkova O.V. — collection and processing of the study data;

Bannikova M.V. — statistical analyses of the data.

All co-authors — approval of the final version of the article, responsibility for the integrity of all parts of the article.

Acknowledgments. The reported study was performed under the government contract no. 11.307.19.2 as of 16.08.2019 with the Federal Medical Biological Agency «Assessment of the nuclear security provisions aimed to identify current and long-term radiological implications for health of citizens exposed to ionizing radiation» (code name «Provisions»).

Conflict of interest. The authors declare no conflict of interest. 

About the authors

Anna V. Rumyantseva

Federal State Unitary Enterprise Southern Urals Biophysics Institute

Author for correspondence.
Email: noemail@neicon.ru
ORCID iD: 0000-0002-3056-3395
Russian Federation

Tamara V. Azizova

Federal State Unitary Enterprise Southern Urals Biophysics Institute

Email: clinic@subi.su
ORCID iD: 0000-0001-6954-2674

MD, PhD, Deputy Director on science, head of clinical Department of Southern Ural Institute of Biophysics, Ozyorsk, 456780, Russian Federation.

e-mail: clinic@subi.su

Russian Federation

Mariya V. Bannikova

Federal State Unitary Enterprise Southern Urals Biophysics Institute

Email: noemail@neicon.ru
ORCID iD: 0000-0002-2755-6282
Russian Federation

Ol’ga V. Zubkova

Federal State Unitary Enterprise Southern Urals Biophysics Institute

Email: noemail@neicon.ru
ORCID iD: 0000-0002-0361-3326
Russian Federation

References

  1. Baysalbaeva A.S. Regimens in radiation therapy of breast cancer. Meditsina i ekologiya. 2016; (3): 8–17. (in Russian)
  2. Mukhanova I.F. Analysis of some indicators of cancer care in breast cancer population of the Republic of Bashkortostan and the Russian Federation. Sovremennye problemy zdravookhraneniya i meditsinskoy statistiki. 2017; (2): 46–56. (in Russian)
  3. Kaprin A.D., Starinskiy V.V., Petrova G.V., eds. Malignant Neoplasms in Russia in 2015: Morbidity and Mortality [Zlokachestvennye novoobrazovaniya v Rossii v 2015 godu: zabolevaemost’ i smertnost’]. Moscow; 2017. (in Russian)
  4. Kaprin A.D., Starinskiy V.V., Petrova G.V., eds. Malignant Neoplasms in Russia in 2017 (Morbidity and Mortality) [Zlokachestvennye novoobrazovaniya v Rossii v 2017 godu (zabolevaemost’ i smertnost’)]. Moscow; 2018. (in Russian)
  5. Mirkhamidova S.M., Dinmukhammadiev N.A. Features of the prevalence of cancer. Molodoy uchenyy. 2016; (20): 84–7. (in Russian)
  6. Sukhareva E.A., Ponomareva L.A. Description of breast diseases of adolescent girls applied to breast office polyclinics. Opukholi reproduktivnoy sistemy. 2013; (1-2): 40–4. (in Russian)
  7. Pisareva L.F., Boyarkina A.P., Panferova E.V., Ananina O.A., Odintsova I.N. Breast cancer incidence among females of Irkutsk region. Risk factors. Sibirskiy onkologicheskiy zhurnal. 2012; (5): 12–7. (in Russian)
  8. Vasil’ev A.A. Etiological features of the incidence of breast cancer in the Orel region. Molodoy uchenyy. 2015; (10): 399–403. (in Russian)
  9. Khudaykulov T.K., Khudaykulov A.T. Assessment of risk factors for breast cancer in women living in the ecologically unfavorable region of the southern Aral Sea in the Khorezm region. Povolozhskiy onkologicheskiy vestnik. 2013; (4): 7–14. (in Russian)
  10. Sukhareva E.A., Ponomareva L.A., Somov A.N. Early diagnosis and prevention of breast cancer in an urban polyclinic. Onkolo-giya. Zhurnal im. P.A. Gertsena. 2013; 1(3): 52–5. (in Russian)
  11. Ostroumova E.V., Preston D.L., Ron I., Krestinina L.Yu., Devis F.G., Kosenko M.M., et al. Breast cancer morbidity in women cohort of Teacha river catchment settlements. Radiatsionnaya epidemiologiya. 2010; 55(3): 37–47. (in Russian)
  12. UNSCEAR-2000. Sources and effects of ionizing radiation. United Nations scientific Committee on the effects of atomic radiation. The 2000 report of UNSCEAR to the General Assembly with scientific annexes (in 4 volumes). New York; 2000.
  13. Rumyantseva A.V., Azizova T.V., Pikulina M.V. Descriptive characteristics of cohort of females professionally exposed to radiation. Problemy reproduktsii. 2015; 21(5): 29–37. (in Russian)
  14. Rumyantseva A.V., Azizova T.V., Bannikova M.V., Zubkova O.V. Characteristics of breast cancer in females occupationally exposed to ionizing radiation. Problemy reproduktsii. 2019; 25(5): 22–9. https://doi.org/10.17116/repro20192505122 (in Russian)
  15. Azizova T.V., Teplyakov I.I., Grigor’eva E.S., Vlasenko E.V., Sumina M.V., Druzhinina M.B., et al. «Clinic» medical dosimetric database for Mayak PA personnel and its families. Meditsinskaya radiologiya i radiatsionnaya bezopasnost’. 2009; 54(5): 26–35. (in Russian)
  16. Petrova G.V., Gretsova O.P., Kaprin A.D., Starinskiy V.V. Characteristics and Methods of Calculating Medical and Statistical Indicators Used in Oncology [Kharakteristika i metody rascheta mediko-statisticheskikh pokazateley, primenyaemykh v onkologii]. Moscow; 2014. (in Russian)
  17. Zhuntova G.V., Azizova T.V., Grigor‘eva E.S., Zavarukhina T.P., Fomin E.P. The indices of morbidity of pancreas cancer in workers of radiation dangerous enterprise. Zdravookhranenie Rossiyskoy Federatsii. 2017; 61(5): 269–75. https://doi.org/10.18821/0044-197X-2017-61-5-269-275 (in Russian)
  18. Chissov V.I., Starinskiy V.V., Kovalev B.N. Organization of the Oncological Service in Russia (Guidelines, Manuals for Doctors). Part 2 [Organizatsiya onkologicheskoy sluzhby v Rossii (metodicheskie rekomendatsii, posobiya dlya vrachey). Chast’ 2]. Moscow; 2007. (in Russian)
  19. Vazhenin A.V., Domozhirova A.S., Aksenova I.A., Ratner E.V. Epidemiological Features of the Cancer Situation and Indicators of the State of Cancer Care to the Population in the Chelya-binsk Region in 2018 [Epidemiologicheskie osobennosti onkologicheskoy situatsii i pokazateli sostoyaniya onkologicheskoy pomoshchi naseleniyu v Chelyabinskoy oblasti v 2018 godu]. Chelyabinsk; 2019. (in Russian)
  20. World Health Organization Classification of tumours of the breast. Available at: https://radiopaedia.org/articles/who-classification-of-tumors-of-the-breast
  21. Azizova T.V., Bannikova M.V., Grigoryeva E.S., Rybkina V.L. Risk of malignant skin neoplasms in a cohort of workers occupationally exposed to ionizing radiation at low dose rates. PLoS One. 2018; 13(10): e0205060. https://doi.org/10.1371/journal.pone.0205060
  22. Portnoy S.M. Main risk factors for breast cancer and proposals for its prevention. Opukholi zhenskoy reproduktivnoy sistemy. 2018; 14(3): 25–39. https://doi.org/10.17650/1994-4098-2018-14-3-25-39 (in Russian)
  23. Vatankha S.S. Epidemiological aspects of breast cancer incidence in Baku. Kazanskiy meditsinskiy zhurnal. 2018; 99(2): 287–90. (in Russian)

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Copyright (c) 2021 Rumyantseva A.V., Azizova T.V., Bannikova M.V., Zubkova O.V.

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