Journal of Modern OncologyJournal of Modern OncologyСовременная онкология1815-14341815-1442LLC Obyedinennaya Redaktsiya8796010.26442/18151434.2021.3.201048CLINICAL ONCOLOGYКЛИНИЧЕСКАЯ ОНКОЛОГИЯResearch ArticleMalignant neoplasm of the bronchi and lung: Russian clinical guidelinesЗлокачественное новообразование бронхов и легкогоhttps://orcid.org/0000-0003-4469-502XLaktionovKonstantin K.ЛактионовКонстантин Константинович
Russian Federation

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subscribe@omnidoctor.ruBlokhin National Medical Research Center of OncologyФГБУ «Национальный медицинский исследовательский центр онкологии им. Н.Н. Блохина» Минздрава РоссииRussian Scientific Center of RoentgenoradiologyФГБУ «Российский научный центр рентгенорадиологии» Минздрава РоссииSaint Petersburg Clinical Research and Practical Center for Specialized Types of Medical Care (Oncologic)ГБУЗ «Санкт-Петербургский клинический научно-практический центр специализированных видов медицинской помощи (онкологический)»Petrov National Medical Research Center of OncologyФГБУ «Национальный медицинский исследовательский центр онкологии им. Н.Н. Петрова» Минздрава РоссииTomsk National Research Medical Center of the Russian Academy of SciencesФГБНУ «Томский национальный исследовательский медицинский центр Российской академии наук»Herzen Moscow Scientifuc Research Institute of Oncology – branch of the National Medical Research Center for RadiologyМосковский научно-исследовательский онкологический институт им. П.А. Герцена – филиал ФГБУ «Национальный медицинский исследовательский центр радиологии» Минздрава РоссииRepublican Clinical Oncology Center of Ministry of Healthcare of the Republic of BashkortostanГБУЗ «Республиканский клинический онкологический диспансер Министерства здравоохранения Республики Башкортостан»Burdenko Main Military Clinical HospitalФГБУ «Главный военный клинический госпиталь им. акад. Н.Н. Бурденко» Минобороны РоссииRostov Research Institute of OncologyФГБУ «Ростовский научно-исследовательский онкологический институт» Минздрава РоссииRussian Medical Academy of Continuous Professional EducationФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава РоссииTsyb Medical Radiological Scientific Center – branch of the National Medical Research Center for RadiologyМедицинский радиологический научный центр им. А.Ф. Цыба – филиал ФГБУ «Национальный медицинский исследовательский центр радиологии» Минздрава РоссииNational Medical Research Center of Rehabilitation and BalneologyФГБУ «Национальный медицинский исследовательский центр реабилитации и курортологии» Минздрава РоссииBurdenko Voronezh State Medical UniversityФГБОУ ВО «Воронежский государственный медицинский университет им. Н.Н. Бурденко» Минздрава РоссииBranch of Kirov Military Medical AcademyФилиал ФГБВОУ ВО «Военно-медицинская академия им. С.М. Кирова» Минобороны РоссииAlbrecht Federal Scientific Center for Rehabilitation of Disabled PeopleФГБУ «Федеральный научный центр реабилитации инвалидов им. Г.А. Альбрехта» Минтруда РоссииMechnikov North-Western State Medical UniversityФГБОУ ВО «Северо-Западный государственный медицинский университет им. И.И. Мечникова» Минздрава РоссииDiagnostic and Rehabilitation Center “Recovery”Центр диагностики и реабилитации «Восстановление»191120212333694021411202114112021Copyright ©; 2021, Consilium MedicumCopyright ©; 2021, ООО "Консилиум Медикум"2021Consilium MedicumООО "Консилиум Медикум"https://creativecommons.org/licenses/by-nc/4.0https://modernonco.orscience.ru/1815-1434/article/view/87960

Lung cancer has the highest morbidity rate among all malignant tumors in men and the highest mortality rate in men and women in Russia. In total, 49 145 new cases of lung cancer were registered (diagnosed) in Russia in 2019. The majority of cases are related to exogenic carcinogens and mainly tobacco smoke. For several decades surgical resection with preoperative cytotoxic therapy was an optimal approach for maximal cure rate. This year recommendations were updated with new strategies including adjuvant anti-PD-L1 atezolizumab following completion of chemotherapy in PD-L1 positive patients and osimertinib for EGFR mutated cases. For this moment available data suggest the increase in disease free survival. Strategic approach to treatment for inoperable patients varies according to the status of driver mutations. New approach includes pretreatment option of testing for a wide spectrum of alterations with NGS based panels. Significant changes were incorporated into treatment of ALK mutated NSCLC with two new options of brigatinib for TKI naive patients and lorlatinib for those who progress on second generation drugs. Treatment strategy for patients without activating mutations is based on PD-L1 status. Tsis year recommendations included atezolizumab as a new monotherapy option for patients with high depression of PD-L1. Also treatment options for pembrolizumab, nivolumab and atezolizimab were widened with prolonged treatment schedules.

Рак легкого (РЛ) – собирательное понятие, объединяющее разные по происхождению, гистологической структуре, клиническому течению и результатам лечения злокачественные эпителиальные опухоли. Развиваются они из покровного эпителия слизистой оболочки бронхов, бронхиальных слизистых желез бронхиол и легочных альвеол [1, 2].

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