Journal of Modern OncologyJournal of Modern OncologyСовременная онкология1815-14341815-1442LLC Obyedinennaya Redaktsiya7051210.26442/18151434.2021.1.200745CLINICAL ONCOLOGYКЛИНИЧЕСКАЯ ОНКОЛОГИЯReview ArticleThe role of positron emission tomography in different types of malignant lymphomas: the results of 2020Роль позитронно-эмиссионной томографии при различных вариантах злокачественных лимфом: итоги 2020 годаhttps://orcid.org/0000-0001-7164-6595SarzhevskiyVladislav O.СаржевскийВладислав Олегович
Russian Federation

D. Sci. (Med.)

Доктор мед. наук, проф. каф. гематологии и клеточной терапии

vladsar100@gmail.comhttps://orcid.org/0000-0002-7716-5896MukhortovaOlga V.МухортоваОльга Валентиновна
Russian Federation

D. Sci. (Med.)

Доктор мед. наук, проф. каф. лучевой диагностики, вед. науч. сотр. отд-ния позитронно-эмиссионной томографии отд. ядерной диагностики

vladsar100@gmail.comPirogov National Medical and Surgical CenterФГБУ «Национальный медико-хирургический центр им. Н.И. Пирогова» Минздрава РоссииBakulev National Medical Research Center for Cardiovascular SurgeryФГБУ «Национальный медицинский исследовательский центр сердечно-сосудистой хирургии им. А.Н. Бакулева» Минздрава России190520212311922001205202112052021Copyright ©; 2021, Consilium MedicumCopyright ©; 2021, ООО "Консилиум Медикум"2021Consilium MedicumООО "Консилиум Медикум"https://creativecommons.org/licenses/by-nc/4.0https://modernonco.orscience.ru/1815-1434/article/view/70512

The review presents the results of studies published in 2020 concerning the role of positron emission tomography (PET) in the diagnosis of different types of malignant lymphomas. The authors tried to highlight the current trends in the development of the PET method in case of Hodgkin lymphoma, diffuse large B-cell lymphoma, follicular lymphoma and multiple myeloma. The topic concerning the use of PET in immunotherapy is highlighted separately. There was also an emphasis on the interpretation of quantitative imaging biomarkers used in PET. The concept of PET-adapted approach in Hodgkin lymphoma, the predictive significance of PET before high-dose chemotherapy and autologous hematopoietic stem cell transplantation in patients with diffuse large B-cell lymphoma, predictive value of intermediate PET in case of follicular lymphoma, the application of methionine as PET tracer to diagnose tumor burden and to measure minimal residual disease in case of multiple myeloma, the variants of atypical tumor response to the immune checkpoint inhibitors therapy, PET in diagnosing immune-mediated adverse events are currently relevant for oncologists, hematologists, radiologists and discussed in this article. In the context of the topics the authors showed the results of PET imaging of Russian patients who had PET examination in the Bakulev National Medical Research Center for Cardiovascular Surgery.

В обзоре представлены результаты исследований, опубликованных в 2020 г. и касающихся роли позитронно-эмиссионной томографии (ПЭТ) в диагностике различных вариантов злокачественных лимфом. Авторы постарались выделить современные тенденции развития метода ПЭТ при лимфоме Ходжкина, диффузной В-крупноклеточной лимфоме, фолликулярной лимфоме и множественной миеломе. Отдельно освещена тема использования ПЭТ при иммунотерапии. Также сделан акцент на интерпретации количественных биомаркеров, оцениваемых при ПЭТ. Концепция ПЭТ-адаптированного подхода при лимфоме Ходжкина, прогностическая значимость ПЭТ перед высокодозной химиотерапией с трансплантацией аутологичных гемопоэтических стволовых клеток у пациентов с диффузной В-крупноклеточной лимфомой, прогностическая ценность промежуточной ПЭТ при фолликулярной лимфоме, использование метионина в качестве радиофармпрепарата для диагностики распространения опухоли и оценки минимальной остаточной болезни при множественной миеломе, варианты атипичного ответа опухоли на терапию ингибиторами иммунных контрольных точек, ПЭТ в диагностике иммуноопосредованных нежелательных явлений – темы, актуальные для онкологов, гематологов, радиологов и обсуждаемые в данной статье. В контексте обсуждаемых тем авторы приводят результаты исследований российских пациентов, проходивших ПЭТ-диагностику в ФГБУ «НМИЦ ССХ им. А.Н. Бакулева» Минздрава России.

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