Journal of Modern OncologyJournal of Modern Oncology1815-14341815-1442LLC Obyedinennaya Redaktsiya7047710.26442/18151434.2021.1.200785Research ArticleTreatment of metastatic hepatocellular carcinoma with lenvatinib. Case report and literature reviewMenshikovKonstantin V.<p>Cand. Sci. (Med.)</p>kmenshikov80@bk.ruhttps://orcid.org/0000-0003-3734-2779SultanbaevAleksandr V.<p>Cand. Sci. (Med.)</p>rkodrb@yandex.ruhttps://orcid.org/0000-0003-0996-5995AkhmetgareevaKamila T.<p>Graduate Student</p>dr.camilaakhmetgareeva@gmail.comhttps://orcid.org/0000-0003-0773-1239LipatovDanila O.<p>Student</p>lipatov911@gmail.comhttps://orcid.org/0000-0002-3193-9008Bashkir State Medical UniversityRepublican Clinical Oncological Dispensary190520212311561611105202111052021Copyright © 2021, Consilium Medicum2021<p>Hepatocellular carcinoma (HCC) or liver cancer is the most common primary malignant tumor of the liver, which is characterized on the first place by a poor prognosis. HCC was diagnosed in 92 patients (62.6%) in 2019 and the period from January to April 2020 in the Republic of Bashkortostan, and among them, 68.47% had stage IV cancer. International professional guidelines suggest screening for early HCC detection. Systemic drug therapy is the treatment of choice for inoperable HCC according to professional guidelines. Inhibition of the VEGF pathway is one of the current methods of therapy for advanced HCC. Lenvatinib is a tyrosine kinase inhibitor for the treatment of advanced HCC that is not subject to local interventions. This article provides a description of a clinical case of successful treatment of a 67-year-old patient with advanced hepatocellular carcinoma. He was appointed for targeted therapy with lenvatinib for HCC that was not subject to local interventions, which led to long-term stabilization. There was a positive trend in the patients condition from the first weeks of therapy. The working capacity was restored. 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