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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Journal of Modern Oncology</journal-id><journal-title-group><journal-title xml:lang="en">Journal of Modern Oncology</journal-title><trans-title-group xml:lang="ru"><trans-title>Современная онкология</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1815-1434</issn><issn publication-format="electronic">1815-1442</issn><publisher><publisher-name xml:lang="en">LLC Obyedinennaya Redaktsiya</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">29498</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">Podderzhivayushchaya terapiya pri metastaticheskom kolorektal'nom rake: odin iz variantov vybora ili novyy standart lecheniya?</article-title><trans-title-group xml:lang="ru"><trans-title>Поддерживающая терапия при метастатическом колоректальном раке: один из вариантов выбора или новый стандарт лечения?</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Artamonova</surname><given-names>E V</given-names></name><name xml:lang="ru"><surname>Артамонова</surname><given-names>Е В</given-names></name></name-alternatives><bio xml:lang="ru"><p>ФГБУ Российский онкологический научный центр им. Н.Н.Блохина РАМН, Москва</p></bio><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en"></institution></aff><aff><institution xml:lang="ru">ФГБУ Российский онкологический научный центр им. Н.Н.Блохина РАМН, Москва</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2012-09-15" publication-format="electronic"><day>15</day><month>09</month><year>2012</year></pub-date><volume>14</volume><issue>3</issue><issue-title xml:lang="en">NO3 (2012)</issue-title><issue-title xml:lang="ru">ТОМ 14, №3 (2012)</issue-title><fpage>20</fpage><lpage>24</lpage><history><date date-type="received" iso-8601-date="2020-04-09"><day>09</day><month>04</month><year>2020</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2012, Consilium Medicum</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2012, ООО "Консилиум Медикум"</copyright-statement><copyright-year>2012</copyright-year><copyright-holder xml:lang="en">Consilium Medicum</copyright-holder><copyright-holder xml:lang="ru">ООО "Консилиум Медикум"</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://modernonco.orscience.ru/1815-1434/article/view/29498">https://modernonco.orscience.ru/1815-1434/article/view/29498</self-uri><abstract xml:lang="en"><p/></abstract><trans-abstract xml:lang="ru"><p/></trans-abstract></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>1. http://www.cancer.org/acs/groups/content/@epidemiologysurveilance/documents/document/acspc-027766.pdf (GLOBOCAN 2008 (IARC). Section of Cancer Information (2011); p. 13. Int J Cancer 2010, 127 (I 12): 2893-917.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>2. Myers MH, Gloeckler LA. Cancer patients survival rates. CA 1989; 39: 21.</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>3. Wingo PA, Tong T, Bolden S. Cancer statistics. CA 1995; 45: 8-30.</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>4. Weitz J, Koch M, Debus J et al. Colorectal cancer. Lancet 2005; 365: 153-65.</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>5. Grothey А, Sargent D, Goldberg RM et al. Survival of patients with advanced colorectal cancer improves with the availability of fluorouracil-leucovorin, irinotecan, and oxaliplatin in the course of treatment. J Clin Oncol 2004; 22: 1209-14.</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>6. Toxicity of fluorouracil in patients with advanced colorectal cancer: effect of administration schedule and prognostic factors. Meta-Analysis Group In Cancer. J Clin Oncol 1998; 16 (11): 3537-41.</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>7. Saltz LB, Clarke S, Díaz-Rubio E et al. Bevacizumab in combination with oxaliplatin-based chemotherapy as first-line therapy in metastatic colorectal cancer: A randomized phase III study. JCO 2008; 26: 2012-9.</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>8. Cassidy J, Clarke S, Díaz-Rubio E et al. XELOX vs FOLFOX-4 as first-line therapy for metastatic colorectal cancer: NO16966 updated results. Br J Cancer 2011; 105 (1): 58-64.</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>9. Grothey A. A comparison of XELOX with FOLFOX-4 as first-line treatment for metastatic colorectal cancer. Nat Clin Pract Oncol 2009; 6 (1): 10-1.</mixed-citation></ref><ref id="B10"><label>10.</label><mixed-citation>10. Tournigand C, André T, Achille E et al. FOLFIRI followed by FOLFOX6 or the reverse sequence in advanced colorectal cancer: a randomized GERCOR study. J Clin Oncol 2004; 22 (2): 229-37.</mixed-citation></ref><ref id="B11"><label>11.</label><mixed-citation>11. Jordan K, Kellner O, Kegel T et al. Phase II trial of capecitabine/irinotecan and capecitabine/oxaliplatin in advanced gastrointestinal cancers. Clin Colorectal Cancer 2004; 4 (1): 46-50.</mixed-citation></ref><ref id="B12"><label>12.</label><mixed-citation>12. Goldberg RM, Sargent DJ, Morton RF et al. A randomized controlled trial of fluorouracil plus leucovorin, irinotecan, and oxaliplatin combinations in patients with previously untreated metastatic colorectal cancer. J Clin Oncol 2004; 22: 23-30.</mixed-citation></ref><ref id="B13"><label>13.</label><mixed-citation>13. Falcone A, Ricci S, Brunetti I et al. Phase III trial of infusional fluorouracil, leucovorin, oxaliplatin, and irinotecan (FOLFOXIRI) compared with infusional fluorouracil, leucovorin, and irinotecan (FOLFIRI) as first-line treatment for metastatic colorectal cancer: the Gruppo Oncologico Nord Ovest. J Clin Oncol 2007; 25 (13): 1670-6.</mixed-citation></ref><ref id="B14"><label>14.</label><mixed-citation>14. Tournigand C, Cervantes A, Figer A et al. OPTIMOX1: A randomized study of FOLFOX4 or FOLFOX7 with oxaliplatin stop-and-go fashion in advanced colorectal cancer - a GERCOR study. JCO 2006; 24: 394-400.</mixed-citation></ref><ref id="B15"><label>15.</label><mixed-citation>15. Chibaudel B, Maindrault-Goebel F, Lledo G et al. Can chemotherapy be discontinued in unresectable metastatic colorectal cancer? The GERCOR OPTIMOX2 Study. JCO 2009; 27: 5727-33.</mixed-citation></ref><ref id="B16"><label>16.</label><mixed-citation>16. Perez-Staub N, Chibaudel, B, Figer A et al. Who can benefit from chemotherapy holidays after first-line therapy for advanced colorectal cancer? A GERCOR study. J Clin Oncol 2008; 26 (Suppl.): 4037.</mixed-citation></ref><ref id="B17"><label>17.</label><mixed-citation>17. Adams RA, Meade AM, Seymour MT et al. Intermittent versus continuous oxaliplatin and fluoropyrimidine combination chemotherapy for first-line treatment of advanced colorectal cancer: results of the randomised phase 3 MRC COIN trial. Lancet Oncol 2011; 12 (7): 642-53.</mixed-citation></ref><ref id="B18"><label>18.</label><mixed-citation>18. Maughan TS, Adams RA, Smith CG et al. Addition of cetuximab to oxaliplatin-based first-line combination chemotherapy for treatment of advanced colorectal cancer: results of the randomised phase 3 MRC COIN trial. Lancet 2011; 377 (9783): 2103-14.</mixed-citation></ref><ref id="B19"><label>19.</label><mixed-citation>19. Labianca R, Sobrero A, Isa L et al. Intermittent versus continuous chemotherapy in advanced colorectal cancer: a randomised 'GISCAD' trial. Ann Oncol 2011; 22: 1236-42.</mixed-citation></ref><ref id="B20"><label>20.</label><mixed-citation>20. Kabbinavar F, Hurwitz HL, Fehrenbacher L et al. Phase II randomized trial comparing bevacizumab plus fluorouracil (FU)/leucovorin (LV) with FU/LV alone in patients with metastatic colorectal cancer. J Clin Oncol 2003; 21: 60.</mixed-citation></ref><ref id="B21"><label>21.</label><mixed-citation>21. Kabbinavar FF, Schulz J, McCleod M et al. Addition of bevacizumab to bolus fluorouracil and leucovorin in first-line metastatic colorectal cancer: results of a randomized phase II trial. J Clin Oncol 2005; 23: 3697-705.</mixed-citation></ref><ref id="B22"><label>22.</label><mixed-citation>22. Hurwitz H, Fehrenbacher L, Novotny W et al. Bevacizumab plus irinotecan, fluorouracil and leucovorin for metastatic colorectal cancer. N Engl J Med 2004; 350: 2335-42.</mixed-citation></ref><ref id="B23"><label>23.</label><mixed-citation>23. Rosen O, Yi J, Hurwitz HI et al. Clinical benefit of bevacizumab in metastatic colorectal cancer is independent of K-ras mutation status: analysis of phase III study of bevacizumab with chemotherapy in previously untreated metastatic colorectal cancer. Ann Oncol 2008; 19 (Suppl. 6): vi 19, abstr 0-035.</mixed-citation></ref><ref id="B24"><label>24.</label><mixed-citation>24. Hurwitz HI, Yi J, Ince W et al. The clinical benefit of bevacizumab in metastatic colorectal cancer is independent of K-ras mutation status: analysis of phase III study of bevacizumab with chemotherapy in previously untreated metastatic colorectal cancer. Oncologist 2009; 14 (1): 22-8.</mixed-citation></ref><ref id="B25"><label>25.</label><mixed-citation>25. Saltz LB, Clarke S, Diaz-Rubio E at al. Bevacizumab (Bev) in combination with XELOX or FOLFOX4: efficacy results from XELOX-1/NO16966, a randomized phase III trial in the first-line treatment of metastatic colorectal cancer (MCRC). GI Cancers Symposium, 2007; abstr. 238.</mixed-citation></ref><ref id="B26"><label>26.</label><mixed-citation>26. Grothey A, Sugrue MM, Purdie DM et al. Bevacizumab beyond first progression is associated with prolonged overall survival in metastatic colorectal cancer: Results from a large observational cohort study (BRiTE). J Clin Oncol 2008; 26: 5326-34.</mixed-citation></ref><ref id="B27"><label>27.</label><mixed-citation>27. Cohn AL, Bekaii-Saab T, Bendell JC et al. Clinical outcomes in bevacizumab (BV)-treated patients (pts) with metastatic colorectal cancer (mCRC): Results from ARIES observational cohort study (OCS) and confirmation of BRiTE data on BV beyond progression (BBP). J Clin Oncol 2010; 28 (Suppl. 15): 3596.</mixed-citation></ref><ref id="B28"><label>28.</label><mixed-citation>28. Arnold D, Andre T, Bennouna J et al. Bevacizumab plus chemotherapy continued beyond first progression in patients with metastatic colorectal cancer previously treated with bevacizumab plus chemotherapy: results of randomized phase III intergroup study. J Clin Oncol 2012, 30 (Suppl. 15): abstr. CRA 3503.</mixed-citation></ref><ref id="B29"><label>29.</label><mixed-citation>29. Grothey A, Hart LL, Rowland KM et al.. Intermittent oxaliplatin (oxali) administration and time-to-treatment-failure (TTF) in metastatic colorectal cancer (mCRC): Final results of the phase III CONcePT trial. JCO 2008; 26 (Suppl. 15): 4010.</mixed-citation></ref><ref id="B30"><label>30.</label><mixed-citation>30. Yalcin S, Uslu R, Dane F et al. A randomised, multicenter phase III trial of bevacizumab plus capecitabine as maintenance treatment after initial treatment with bevacizumab plus XELOX in previously untreated metastatic colorectal cancer. JCO 2011; 11 (Suppl. 4): 474.</mixed-citation></ref><ref id="B31"><label>31.</label><mixed-citation>31. Tabernero J, Aranda E, Gomez A et al. Phase III study of first-line XELOX plus bevacizumab (BEV) for 6 cycles followed by XELOX plus bevacizumab or singl-agent (s/a) BEV as maintenance therapy in patients (pts) with metastatic colorectal cancer (mCRC): The MACRO Trial (Spanish Cooperative Group for the Treatment of Digestive Tumors [TTD]). JCO 2010; 28 (Suppl. 15): 3501.</mixed-citation></ref><ref id="B32"><label>32.</label><mixed-citation>32. Diaz-Rubio E, Gomaz-Espana A, Massuti B et al. First-Line XELOX Plus Bevacizumab Followed by XELOX Plus Bevacizumab or Single-Agent Bevacizumab as Maintenance Therapy in Patients with Metastatic Colorectal Cancer: The Phase III MACRO. Oncologist 2012; 17: 15-25.</mixed-citation></ref><ref id="B33"><label>33.</label><mixed-citation>33. http://clinicaltrials.gov/ct2/show/NCT00973609. Randomized three arm phase III trial on induction treatment with a fluoropyrimidine-, oxaliplatin- and bevacizumab-based chemotherapy for 24 weeks followed by maintenance treatment with a fluoropyrimidine and bevacizumab vs. bevacizumab alone vs. no maintenance treatment and reinduction in case of progression for first-line treatment of patients with metastatic colorectal cancer.</mixed-citation></ref></ref-list></back></article>
