Journal of Modern OncologyJournal of Modern Oncology1815-14341815-1442LLC Obyedinennaya Redaktsiya27168Research ArticleDermatomyositis and polymyositis in breast cancer patients: a case reportsGanshinaI P-ZhukovaL G-BurnevitchE Zganshinainna77@mail.ruGordeevaO O-KondratievaO E-N.N.Blokhin National Medical Research Center of Oncology of the Ministry of Health of the Russian FederationI.M.Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation15032018201424409042020Copyright © 2018, Consilium Medicum2018Dermatomyositis and polymyositis are an autoimmune disease which is characterized by proximal skeletal muscle weakness, muscle inflammation and associated with a variety of skin manifestations. Both autoimmune conditions are mainly observed as an independent disease, though an association between dermato- and polymyositis and malignancy were described. Case reports of two patients are presented, in one of which dermatomyositis and breast cancer were manifested simultaneously, in the other - the development of polymyositis preceded the recurrence of the disease after a long-term remission. Also diagnostic and therapeutic options of both conditions are shown.dermatomyositispolymyositisbreast cancerparaneoplastic syndromeanti-HER2 therapyдерматомиозитрак молочной железыпаранеопластический синдроманти-HER2 терапия[Dalakas M.C, Hohlfeld R. Polymyositis and dermatomyositis. Lancet 2003; 362 (9388): 971.][Zantos D, Zhang Y, Felson D. The overall and temporal association of cancer with polymyositis and dermatomyositis. J Rheumatol 1994; 21: 1855-9.][Barnes B.E, Mawr B. Dermatomyositis and malignancy. A review of the literature. Ann Intern Med 1976; 84 (1): 68.][Sigurgeirsson B, Lindelöf B et al. Risk of cancer in patients with dermatomyositis or polymyositis. A population-based study. N Engl J Med 1992; 326 (6): 363.][Rai S.K, Choi H.K et al. Risk of myocardial infarction and ischaemic stroke in adults with polymyositis and dermatomyositis: a general population-based study. Rheumatology (Oxford). 2016; 55 (3): 461-9. Epub 2015 Sep 30.][Mimori T, Imura Y et al. Autoantibodies in idiopathic inflammatory myopathy: an update on clinical and pathophysiological significance. Curr Opin Rheumatol 2007; 19 (6): 523.][Brouwer R, Hengstman G.J. et al. Autoantibody profiles in the sera of European patients with myositis. Ann Rheum Dis 2001; 60 (2): 116.][Koenig M, Fritzler M.J et al. Heterogeneity of autoantibodies in 100 patients with autoimmune myositis: insights into clinical features and outcomes. Arthritis Res Ther 2007; 9 (4): R78.][Колядина И.В., Поддубная И.В. Современные возможности терапии HER2-положительного рака молочной железы (по материалам клинических исследований). Современ. онкология. 2014; 4: 10-21.][Колядина И.В., Поддубная И.В. и др. Гетерогенность рака молочной железы I стадии: биологическое и прогностическое значение. Злокачественные опухоли. 2015; 1: 31-42.][Hendren E, Vinik O. Breast cancer and dermatomyositis: a case study and literature review. Curr Oncol 2017; 24 (5): e429-e433.]