Journal of Modern OncologyJournal of Modern OncologyСовременная онкология1815-14341815-1442LLC Obyedinennaya Redaktsiya27045ArticlesСтатьиResearch ArticleCurrent understanding of the role of insulin-like and vascular endothelial growth factors in development, prognosis and targeted therapy in patients with ovarian cancerСовременные представления о роли инсулиноподобных и вазоэндотелиальных факторов роста в развитии, прогнозе и таргетной терапии рака яичниковKnyazevR IКнязевРостислав Игоревич

аспирант каф. онкологии ГБОУ ДПО РМАПО

sluwba@mail.ruPoddubnayaI VПоддубнаяИрина Владимировна

д-р мед. наук, проф., чл.-кор. РАН, зав. каф. онкологии ГБОУ ДПО РМАПО

BarinovV VБариновВладимир Васильевич

д-р мед. наук, проф., вед. науч. сотр. отд-ния гинекологии ФГБУ РОНЦ им. Н.Н.Блохина

BokinI IБокинИван Игоревич

канд. мед. наук, ассистент каф. онкологии ГБОУ ДПО РМАПО

Russian Medical Academy of Postgraduate Education of the Ministry of Health of the RussianГБОУ ДПО Российская медицинская академия последипломного образования Минздрава РоссииN.N.Blokhin Russian Cancer Research CenterФГБУ Российский онкологический научный центр им. Н.Н.Блохина Минздрава России15092015173VOL 17, NO3 (2015)ТОМ 17, №3 (2015)10510809042020Copyright ©; 2015, Consilium MedicumCopyright ©; 2015, ООО "Консилиум Медикум"2015Consilium MedicumООО "Консилиум Медикум"https://creativecommons.org/licenses/by-nc/4.0https://modernonco.orscience.ru/1815-1434/article/view/27045

The system of the insulin-like growth factors (IGF) through its mitogenic and antiapoptotic effects plays an important role in carcinogenesis. IGF with interaction with own receptor activates Ras - and Akt-signaling pathways that lead to enhanced cell proliferation and reduction of apoptosis. Via stimulation of proangiogenic factors, such as vascular endothelial growth factor (VEGF), IGF also mediates processes of neoangiogenesis that are necessary for the development, progression and metastasis of malignant tumors. Recent data show a linkage between IGF, VEGF and ovarian cancer. New drugs of targeted therapy for patients with ovarian adenocarcinoma, that inhibit the components of IGF and VEGF families, are under experimental and clinical trials. This review presents the results of investigations of IGF′ and VEGF′ role in the development, prognosis and treatment of patients with ovarian cancer.

Система инсулиноподобных факторов роста (ИФР) посредством своих митогенных и антиапоптотических эффектов играет немаловажную роль в канцерогенезе. При взаимодействии со своим рецептором ИФР активирует Ras- и Akt-сигнальные пути, что приводит к усилению клеточной пролиферации и угнетению апоптоза. Через стимуляцию проангиогенных факторов, в том числе и фактора роста эндотелия сосудов (VEGF - vascular endothelial growth factor), ИФР-сигнальный путь также опосредует процессы неоангиогенеза, необходимые для развития, прогрессирования и метастазирования злокачественных новообразований. Работы последних лет установили связь между ИФР, VEGF и раком яичников. Новые лекарственные препараты таргетной терапии больных карциномой яичника, направленные на подавление компонентов системы ИФР и VEGF, находятся на стадии экспериментальных и клинических исследований. В обзоре литературы представлены результаты изучения роли ИФР и VEGF в развитии, прогнозе и лечении пациенток, страдающих злокачественными новообразованиями яичников.

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