Journal of Modern OncologyJournal of Modern Oncology1815-14341815-1442LLC Obyedinennaya Redaktsiya26972Research ArticlePrognostic significance of dynamics of biochemical markers of neuroendocrine tumors during treatment with biotherapyEmelianovaG S-GorbunovaV A-LubimovaN V-OrelN F-MarkovichA A-SelchukV U-15062014162778109042020Copyright © 2014, Consilium Medicum2014Dynamic of biochemical markers of neuroendocrine tumors (chromogranin A, serotonin, 5-hydroxyindoleacetic acid) are predictive factorsof biotherapy efficacy. We found that 30% decreasing of biochemical markers within 6 months improves median of time to progression for patients with neuroendocrine tumors.neuroendocrine tumorsbiochemical markerschromogranin Aserotonin5-hydroxyindoleacetic acidнейроэндокринные опухолибиохимические маркерыхромогранин Асеротонин5-гидроксииндолуксусная кислота[Yao J-C, Hassan M, Phan A et al. One hundred years after “carcinoid”: epidemiology of and prognostic factors for neuroendocrine tumors in 35,825 cases in the United States. J Clin Oncol 2008; 26: 3063-72.][Горбунова В.А., Егоров А.В., Кочатков А.В. Нейроэндокринные опухоли желудочно - кишечного тракта. Принципы диагностики и лечения. М.: Б.И. 2009; с. 196.][Stridsberg M, Oberg K, Engstrom U, Lundquist G. Measurements of chromogranin A, chromogranin В (secretogranin I), chromogranin С (secretogranin II) and pancreostatin in plasma and urina from patients with carcinoid tumours. J Endocrinol 1995; 144: 49-59.][Любимова Н.В., Костылева О.И., Маркович А.А. Биохимические маркеры нейроэндокринных опухолей: методические и клинические аспекты. Вестник. 2010; 10.][Kolby L, Bernhardt P, Sward C et al. Chromogranin A as a determinant of midgut carcinoid tumour volume. Regul Pept 2004; 120 (1-3): 269-73.][Yao J.C, Pavel M, Phan A.T et al. Chromogranin A and Neuron - specific Enolase as prognostic markers in patients with advanced pNET treated with Everolimus. J Clin Endocrinol Metab 2011; 96 (12): 3741-9.]