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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Journal of Modern Oncology</journal-id><journal-title-group><journal-title xml:lang="en">Journal of Modern Oncology</journal-title><trans-title-group xml:lang="ru"><trans-title>Современная онкология</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1815-1434</issn><issn publication-format="electronic">1815-1442</issn><publisher><publisher-name xml:lang="en">LLC Obyedinennaya Redaktsiya</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">26953</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Clinical cases of treatment of hepatocellular carcinoma</article-title><trans-title-group xml:lang="ru"><trans-title>Клинические случаи лечения гепатоцеллюлярного рака</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Lazarev</surname><given-names>S A</given-names></name><name xml:lang="ru"><surname>Лазарев</surname><given-names>С А</given-names></name></name-alternatives><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Mamontov</surname><given-names>K G</given-names></name><name xml:lang="ru"><surname>Мамонтов</surname><given-names>К Г</given-names></name></name-alternatives></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Manihas</surname><given-names>G M</given-names></name><name xml:lang="ru"><surname>Манихас</surname><given-names>Г М</given-names></name></name-alternatives><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Antimonik</surname><given-names>N Yu</given-names></name><name xml:lang="ru"><surname>Антимоник</surname><given-names>Н Ю</given-names></name></name-alternatives><xref ref-type="aff" rid="aff3"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en"></institution></aff><aff><institution xml:lang="ru">КГБУЗ Алтайский краевой онкологический диспансер</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="ru">Алтайский филиал ФГБУ РОНЦ им. Н.Н.Блохина РАМН</institution></aff><aff><institution xml:lang="en"></institution></aff></aff-alternatives><aff id="aff3"><institution>СПб ГБУЗ Городской клинический онкологический диспансер</institution></aff><pub-date date-type="pub" iso-8601-date="2014-03-15" publication-format="electronic"><day>15</day><month>03</month><year>2014</year></pub-date><volume>16</volume><issue>1</issue><issue-title xml:lang="en">VOL 16, NO1 (2014)</issue-title><issue-title xml:lang="ru">ТОМ 16, №1 (2014)</issue-title><fpage>65</fpage><lpage>69</lpage><history><date date-type="received" iso-8601-date="2020-04-09"><day>09</day><month>04</month><year>2020</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2014, Consilium Medicum</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2014, ООО "Консилиум Медикум"</copyright-statement><copyright-year>2014</copyright-year><copyright-holder xml:lang="en">Consilium Medicum</copyright-holder><copyright-holder xml:lang="ru">ООО "Консилиум Медикум"</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://modernonco.orscience.ru/1815-1434/article/view/26953">https://modernonco.orscience.ru/1815-1434/article/view/26953</self-uri><abstract xml:lang="en"><p>The article presents the clinical cases of sorafenib treatment of hepatocellular carcinoma. The experience of the Russian oncologistsdoes not only confirm the results of the international clinical research, but also demonstrates the possibility of prolonged administration of the drug for more than 3-4 years against a backdrop of high efficiency and controlled security profile.</p></abstract><trans-abstract xml:lang="ru"><p>В статье представлены клинические случаи применения таргетной терапии препаратом сорафениб для лечения гепато-целлюлярного рака. Опыт российских онкологов не только подтверждает результаты международных клинических исследований, но и наглядно демонстрирует возможности продолжительного приема препарата более 3-4 лет на фоне высокой эффективности и контролируемого профиля безопасности.</p></trans-abstract><kwd-group xml:lang="en"><kwd>hepatocellular carcinoma</kwd><kwd>primary liver cancer</kwd><kwd>targeted therapy</kwd><kwd>sorafenib</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>гепатоцеллюлярный рак</kwd><kwd>первичный рак печени</kwd><kwd>таргетная терапия</kwd><kwd>сорафениб</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Практические рекомендации по лекарственному лечению больных первичным раком печени общества онкологов - химиотерапевтов (RUSSCO). Версия 2013; с. 229-36.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>EASL-EORTC Clinical Practice Guidelines: Management of hepatocellular carcinoma. J Hepatol 2012; 56: 908-43.</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Bruix J, Raoul J.L, Sherman M et al. Efficacy and safety of sorafenib in patients with advanced hepatocellular carcinoma: subanalyses of a phase III trial. J Hepatol 2012; 57 (4): 821-9;</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Llovet J.M, Ricci S, Mazzaferro V et al. Sorafenib in advanced hepatocellular carcinoma. N Engl J Med 2008; 359 (4): 378-90.</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>Marrero J et al. Final analysis of GIDEON (Global Investigation of therapeutic DEcisions in hepatocellular carcinoma and Of its treatment with sorafeNib) in &gt;3000 sorafenib - treated patients: clinical findings in patients with liver dysfunction. Poster presented at the Annual Meeting of the American Society of Clinical Oncology, May 31 - June 4, 2013; Chicago, Illinois USA.</mixed-citation></ref></ref-list></back></article>
