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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Journal of Modern Oncology</journal-id><journal-title-group><journal-title xml:lang="en">Journal of Modern Oncology</journal-title><trans-title-group xml:lang="ru"><trans-title>Современная онкология</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1815-1434</issn><issn publication-format="electronic">1815-1442</issn><publisher><publisher-name xml:lang="en">LLC Obyedinennaya Redaktsiya</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">26946</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Personalized approach to HER2-positive advanced breast cancertherapy</article-title><trans-title-group xml:lang="ru"><trans-title>Персонализированный подход к терапии распространенного HER2- положительного рака молочной железы</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Stenina</surname><given-names>M B</given-names></name><name xml:lang="ru"><surname>Стенина</surname><given-names>Марина Борисовна</given-names></name></name-alternatives><bio xml:lang="ru"><p>вед. науч. сотр.</p></bio><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en"></institution></aff><aff><institution xml:lang="ru">ФГБУ Российский онкологический научный центр им. Н.Н.Блохина Российской академии медицинских наук, Москва</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2014-09-15" publication-format="electronic"><day>15</day><month>09</month><year>2014</year></pub-date><volume>16</volume><issue>3</issue><issue-title xml:lang="en">VOL 16, NO3 (2014)</issue-title><issue-title xml:lang="ru">ТОМ 16, №3 (2014)</issue-title><fpage>21</fpage><lpage>26</lpage><history><date date-type="received" iso-8601-date="2020-04-09"><day>09</day><month>04</month><year>2020</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2014, Consilium Medicum</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2014, ООО "Консилиум Медикум"</copyright-statement><copyright-year>2014</copyright-year><copyright-holder xml:lang="en">Consilium Medicum</copyright-holder><copyright-holder xml:lang="ru">ООО "Консилиум Медикум"</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://modernonco.orscience.ru/1815-1434/article/view/26946">https://modernonco.orscience.ru/1815-1434/article/view/26946</self-uri><abstract xml:lang="en"><p>Anti-HER2 therapy is a standard component of drug therapy for HER2-positive breast cancer. The advent of new drugs of this group creates additional possibilities for treatment and necessitates for creating an algorithm according to the characteristics of each patient. We analyzed possible therapeutic options concerning international guidelines for treating HER2-positive advanced breast cancer.</p></abstract><trans-abstract xml:lang="ru"><p>Анти-HER2-терапия является стандартным компонентом лекарственной терапии HER2-положительного рака молочной железы. Появление новых препаратов этой группы создает дополнительные возможности лечения и диктует необходимость создания алгоритма с учетом особенностей конкретного больного. рассмотрены возможные лечебные опции в контексте международных рекомендаций по лечению распространенного HER2-положительного рака молочной железы.</p></trans-abstract><kwd-group xml:lang="en"><kwd>T-DM1</kwd><kwd>advanced breast cancer</kwd><kwd>HER2-targeted therapy</kwd><kwd>trastuzumab</kwd><kwd>lapatinib</kwd><kwd>pertuzumab</kwd><kwd>T-DM1</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>распространенный рак молочной железы</kwd><kwd>анти-HER2-терапия</kwd><kwd>трастузумаб</kwd><kwd>лапатиниб</kwd><kwd>пертузумаб</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Регистр лекарственных средств России 2010-2012. URL: http://www.rlsnet.ru/.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Vogel C.L, Cobleigh M.A, Tripathy D et al. Efficacy and safety of trastuzumab as a single agent in first - line treatment of HER2-overexpressing metastatic breast cancer. J Clin Oncol 2002; 20: 719.</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Longo R, Torino F, Gasparini G. Targeted therapy of breast cancer. Curr Pharm Des 2007; 13: 497-517.</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Slamon D.J, Leyland-Jones B, Shak S et al. Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2. N Engl J Med 2001; 344: 783-92.</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>Marty M, Cognetti F, Maraninchi D et al. Randomized phase II trial of the efficacy and safety of trastuzumab combined with docetaxel in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer administered as first line treatment: the M77001 study group. J Clin Oncol 2005; 23: 4265-74.</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>Gasparini G, Gion M, Mariani L et al. Randomized phase II trial of weekly paclitaxel alone versus trastuzumab plus weekly paclitaxel as first - line therapy of patients with HER-2 positive advanced breast cancer. Breast Cancer Res Treat 2007; 101: 355-65.</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>von Minckwitz G, du Bois A, Schmidt M et al. Trastuzumab beyond progression in human epidermal growth factor receptor 2-positive advanced breast cancer: a German Breast Group 26/Breast International Group 03-05 Study. J Clin Oncol 2009; 27: 1999-2006.</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>Bartsch R, Wenzel C, Gampenrieder S.P et al. Trastuzumab and gemcitabine as salvage therapy in heavily pretreated patients with metastatic breast cancer. Cancer Chemother Pharmacol 2008; 62: 903-10.</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>Cardoso F, Costa A, Norton L et al. 1st International consensus guidelines for advanced breast cancer. Breast 2012; 21: 242-52.</mixed-citation></ref><ref id="B10"><label>10.</label><mixed-citation>Gomez H.L, Doval D.C, Chavez M.A et al. Efficacy and safety of lapatinib as first - line therapy for ErbB2-amplified locally advanced or metastatic breast cancer. J Clin Oncol 2008; 26: 2999-3005.</mixed-citation></ref><ref id="B11"><label>11.</label><mixed-citation>Guan Z-Z, Xu B-H, Arpornwirat W et al. Overall survival benefit observed with lapatinib plus paclitaxel as first line therapy in patients with HER2-overexpressed metastatic breast cancer. Cancer Res 2010; 10 (Suppl.): Abstract P3-14-24.</mixed-citation></ref><ref id="B12"><label>12.</label><mixed-citation>Di Leo A, Gomez H.L, Aziz Z et al. Phase III double - blind randomized study comparing lapatinib plus paclitaxel with placebo plus paclitaxel as first - line treatment for metastatic breast cancer.</mixed-citation></ref><ref id="B13"><label>13.</label><mixed-citation>Gelmon K.A, Boyle F, Kaufman B et al. Open - label phase III randomized controlled trial comparing taxane - based chemotherapy with lapatinib or trastuzumab as first line therapy for women with HER2+ metastatic breast cancer: Interim analysis of NCIC CTG MA.31/GSK EGF 108919. J Clin Oncol 2012; 30 (Suppl.): Abstract LBA671.</mixed-citation></ref><ref id="B14"><label>14.</label><mixed-citation>Untch M, Loibl S, Bischoff J et al. Lapatinib versus trastuzumab in combination with neoadjuvant anthracycline - taxane - based chemotherapy (GeparQuinto, GBG 44): a randomised phase 3 trial. Lancet Oncol 2012; 13: 135-44.</mixed-citation></ref><ref id="B15"><label>15.</label><mixed-citation>Geyer C.E, Forster J, Lindquist D et al. Lapatinib plus capecitabine for HER2-positive advanced breast cancer. N Engl J Med 2006; 355: 2733-43.</mixed-citation></ref><ref id="B16"><label>16.</label><mixed-citation>Cameron D, Casey M, Oliva C et al. Lapatinib plus capecitabin in women with HER-2-positive advanced breast cancer: final survival analysis of a phase III randomized trial. Oncologist 2010; 15: 924-34.</mixed-citation></ref><ref id="B17"><label>17.</label><mixed-citation>Magdelaine-Beuzelin С, Kaas Q, Wehbi V et al. Structure - function relationships of the variable domains of monoclonal antibodies approved for cancer treatment. Crit Rev Oncol Hematol 2007; 64: 210-25.</mixed-citation></ref><ref id="B18"><label>18.</label><mixed-citation>Baselga J, Cortés J, Kim S.B et al. Pertuzumab plus trastuzumab plus docetaxel for metastatic breast cancer. N Engl J Med 2012; 366: 109-19.</mixed-citation></ref><ref id="B19"><label>19.</label><mixed-citation>Swain S et al. Pertuzumab, trastuzumab, and docetaxel for HER2-positive metastatic breast cancer (CLEOPATRA study): overall survival results from a randomised, double - blind, placebo - controlled, phase 3 study. Lancet Oncology 2013; 14: 461-71.</mixed-citation></ref><ref id="B20"><label>20.</label><mixed-citation>Baselga J, Bradbury I, and Eidtmann H. Lapatinib with trastuzumab for HER2-positive early breast cancer (NeoALTTO): a randomised, open - label, multicentre, phase 3 trial. Lancet 2012; 379 (9816): 616.</mixed-citation></ref><ref id="B21"><label>21.</label><mixed-citation>Guarneri V, Frassoldati A, Bottini A et al. Preoperative chemotherapy plus trastuzumab, lapatinib, or both in human epidermal growth factor receptor 2-positive operable breast cancer: results of the randomized phase II CHER-LOB study. J Clinic Oncol 2012; 30 (16): 1989-95.</mixed-citation></ref><ref id="B22"><label>22.</label><mixed-citation>Robidoux A, Tang G, Rastogi P et al. Evaluation of lapatinib as a component of neoadjuvant therapy for HER2+ operable breast cancer: NSABP protocol B-41. J Clin Oncol 2012; 30: Abstract LBA506.</mixed-citation></ref><ref id="B23"><label>23.</label><mixed-citation>Gianni L, Pienkowski T, Im Y-H et al. Efficacy and safety of neoadjuvant pertuzumab and trastuzumab in women with locally advanced, inflammatory, or early HER2-positive breast cancer (NeoSphere): a randomised multicentre, open - label, phase 2 trial. Lancet Oncology 2012; 13 (1): 25-32.</mixed-citation></ref><ref id="B24"><label>24.</label><mixed-citation>Schneeweiss A, Chia S, Hickish T et al. Neoadjuvant pertuzumab and trastuzumab concurrent or sequential with an anthracycline - containing or concurrent with an anthracycline - free standard regimen: A Randomized Phase II Study (TRYPHAENA). Cancer Res 2011; 71 (24, Suppl. 3): Abstract S5-6.</mixed-citation></ref><ref id="B25"><label>25.</label><mixed-citation>Beck A, Haeuw J.F, Wurch T et al. The next generation of antibody drug conjugates comes from age. Discovery Med 2010; 10 (53): 329-39.</mixed-citation></ref><ref id="B26"><label>26.</label><mixed-citation>Krop I.E, Beeram M, Modi S et al. Phase I study of trastuzumab- DM1, a HER2 antibody - drug conjugate, given every 3 weeks to patients with HER2-positive metastatic breast cancer. J Clin Oncol 2010; 28: 398-405.</mixed-citation></ref><ref id="B27"><label>27.</label><mixed-citation>Blackwell K.L, Miles D, Gianni L et al. Primary results from EMILIA, a phase III study of trastuzumab emtansine (T-DM1) versus capecitabine and lapatinib in HER2-positive locally advanced or metastatic breast cancer previously treated with trastuzumab and a taxane. J Clin Oncol 2012; 30 (Suppl.): Abstract LBA1.</mixed-citation></ref><ref id="B28"><label>28.</label><mixed-citation>Verma S, Miles D, Gianni L et al. Trastuzumab emtansine for HER2-positive advanced breast cancer. N Engl J Med 2012; 367: 1783-91.</mixed-citation></ref><ref id="B29"><label>29.</label><mixed-citation>Hurvitz S.A, Dirix L, Kocsis J et al. Phase II randomized study of trastuzumab emtansine versus trastuzumab plus docetaxel in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer. J Clin Oncol 2013; 31 (9): 1157-63.</mixed-citation></ref><ref id="B30"><label>30.</label><mixed-citation>U.S. FDA. Full Prescribing Information for Kadcyla PDF (556 kB). Retrieved 2012-02-23.</mixed-citation></ref><ref id="B31"><label>31.</label><mixed-citation>Kaufman B, Mackey J.R, Clemens M.R et al. Trastuzumab plus anastrozole versus anastrozole alone for the treatment of postmenopausal women with human epidermal growth factor receptor 2 positive, hormone receptor positive metastatic breast cancer: results from the randomized phase III TAnDEM study. J Clin Oncol 2009; 27: 5529-37.</mixed-citation></ref><ref id="B32"><label>32.</label><mixed-citation>Johnston S, Pippen Jr.J, Pivot X, Lichinitser M et al. Lapatinib combined with letrozole versus letrozole and placebo as first - line therapy for postmenopausal hormone receptor - positive metastatic breast cancer. J Clin Oncol 2009; 27: 5538-46.</mixed-citation></ref><ref id="B33"><label>33.</label><mixed-citation>Huober J, Fasching P.A, Barsoumc M et al. Higher efёcacy of letrozole in combination with trastuzumab compared to letrozole monotherapy as first - line treatment in patients with HER2-positive, hormone - receptor - positive metastatic breast cancer - results of the eLEcTRA trial. Breast 2011; 1: 7.</mixed-citation></ref><ref id="B34"><label>34.</label><mixed-citation>Giordano S.H, Temin S, Kirshner J.J et al. Systemic Therapy for Patients With Advanced Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer: American Society of Clinical Oncology Clinical Practice Guideline. Published online before print: May 5, 2014. DOI: 10.1200/ JCO.2013.54.094.</mixed-citation></ref><ref id="B35"><label>35.</label><mixed-citation>Swain S, Kim S et al. Final overall survival analysis from the CLEOPATRA study of first - line pertuzumab, trastuzumab, and docetaxel in patients with HER2-positive metastatic breast cancer. ESMO 2014: Absract 350O_PR.</mixed-citation></ref></ref-list></back></article>
