Journal of Modern OncologyJournal of Modern OncologyСовременная онкология1815-14341815-1442LLC Obyedinennaya Redaktsiya26938ArticlesСтатьиResearch ArticleOvercoming immunological tolerance is a way of treating malignant tumors: new perspectivesПреодоление иммунной толерантности как способ лечения злокачественных опухолей: новые перспективыSamoilenkoI VСамойленкоИгорь Вячеславович

канд. мед. наук, науч. сотр. отд-ния биотерапии опухолей

i.samoylenko@roncKharkevichG UХаркевичГалина Юрьевна

канд. мед. наук, вед. науч. сотр. отд-ния биотерапии опухолей

DemidovL VДемидовЛев Вадимович

д-р мед. наук, проф., зав. отд-нием биотерапии опухолей

ФГБУ РОНЦ им. Н.Н.Блохина РАМН, Москва15032014161VOL 16, NO1 (2014)ТОМ 16, №1 (2014)424709042020Copyright ©; 2014, Consilium MedicumCopyright ©; 2014, ООО "Консилиум Медикум"2014Consilium MedicumООО "Консилиум Медикум"https://creativecommons.org/licenses/by-nc/4.0https://modernonco.orscience.ru/1815-1434/article/view/26938

This literature review outlines the current knowledge of the mechanisms of antitumor immunity and the role of one of the new classes of immunomodulators blocking immune regulatory molecules CTLA4, which soon could be used by oncology practitioners in Russia and has already been successfully used for the treatment of disseminated melanoma in Europe and the United States. Ipilimumab is the first drug, which represent the class registered on this indication in Europe and the United States. Fundamentally different mode of action from the cytostatic drugs mode of action is required to find another approach to assessing an objective response to treatment and special attention to the different, sometimes unexpected side effects of chemotherapy.

В настоящем обзоре литературы изложены современные представления о механизмах противоопухолевого иммунитета, а также роли одного из классов новых иммуномодуляторов - блокаторов иммунных регуляторных молекул CTLA4, которые в ближайшее время могут оказаться в арсенале практикующих онкологов России и уже с успехом применяются для лечения диссеминированной меланомы кожи в странах Европы и США. Ипилимумаб - первый препарат, представитель класса, зарегистрированный по данному показанию в странах Европы и США. Принципиально отличающийся от цитостатических препаратов механизм действия обусловливает необходимость других подходов к оценке объективного ответа на лечение и особого внимания к разнообразным, иногда неожиданным для химиотерапевтов побочным реакциям.

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