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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Journal of Modern Oncology</journal-id><journal-title-group><journal-title xml:lang="en">Journal of Modern Oncology</journal-title><trans-title-group xml:lang="ru"><trans-title>Современная онкология</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1815-1434</issn><issn publication-format="electronic">1815-1442</issn><publisher><publisher-name xml:lang="en">LLC Obyedinennaya Redaktsiya</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">26915</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Retseptor faktora rosta fibroblastov 1-go tipa kak mishen' tselenapravlennoy terapii pochechno-kletochnogo raka</article-title><trans-title-group xml:lang="ru"><trans-title>Рецептор фактора роста фибробластов 1-го типа как мишень целенаправленной терапии почечно-клеточного рака</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Timofeev</surname><given-names>Il'ya Valer'evich</given-names></name><name xml:lang="ru"><surname>Тимофеев</surname><given-names>Илья Валерьевич</given-names></name></name-alternatives><bio xml:lang="ru"><p>дир. Бюро по изучению рака почки, дир. Общества онкологов-химиотерапевтов, член научного комитета Международной ассоциации по борьбе с раком почки</p></bio><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en"></institution></aff><aff><institution xml:lang="ru">Бюро по изучению рака почки</institution></aff></aff-alternatives><aff id="aff2"><institution>Общество онкологов-химиотерапевтов, Москва</institution></aff><pub-date date-type="pub" iso-8601-date="2013-09-15" publication-format="electronic"><day>15</day><month>09</month><year>2013</year></pub-date><volume>15</volume><issue>3</issue><issue-title xml:lang="en">VOL 15, NO3 (2013)</issue-title><issue-title xml:lang="ru">ТОМ 15, №3 (2013)</issue-title><fpage>56</fpage><lpage>62</lpage><history><date date-type="received" iso-8601-date="2020-04-09"><day>09</day><month>04</month><year>2020</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2013, Consilium Medicum</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2013, ООО "Консилиум Медикум"</copyright-statement><copyright-year>2013</copyright-year><copyright-holder xml:lang="en">Consilium Medicum</copyright-holder><copyright-holder xml:lang="ru">ООО "Консилиум Медикум"</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://modernonco.orscience.ru/1815-1434/article/view/26915">https://modernonco.orscience.ru/1815-1434/article/view/26915</self-uri><abstract xml:lang="ru"><p>Патогенетический путь фактора роста фибробластов и его рецепторов имеет большое значение в развитии и прогрессировании почечно-клеточного рака. Различные его компоненты рассматриваются в качестве мишеней таргетной терапии. Возможно, в ближайшем будущем появятся новые препараты, которые повысят общую эффективность терапии метастатического рака почки и других опухолей.</p></abstract><kwd-group xml:lang="ru"><kwd>почечно-клеточный рак</kwd><kwd>рецептор фактора роста фибробластов 1-го типа</kwd><kwd>резистентность</kwd><kwd>таргетная терапия</kwd><kwd>ангиогенез</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Kluger H.M, Siddiqui S.F, Angeletti C et al. Classification of renal cell carcinoma based on expression of VEGF and VEGF receptors in both tumor cells and endothelial cells. Laboratory Investigation 2008; 88: 962–72.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Rini B.I, Atkins M.B. Resistance to targeted therapy in renal - cell carcinoma. 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