Journal of Modern OncologyJournal of Modern OncologyСовременная онкология1815-14341815-1442LLC Obyedinennaya Redaktsiya26912ArticlesСтатьиResearch ArticleGefitinib – terapiya vybora 1-y linii nemelkokletochnogo raka legkogo u bol'nykh s nalichiem mutatsiy v gene EGFRГефитиниб – терапия выбора 1-й линии немелкоклеточного рака легкого у больных с наличием мутаций в гене EGFRBolotinaLarisa VladimirovnaБолотинаЛариса Владимировна

д-р мед. наук, рук. отд-ния химиотерапии

ФГБУ Московский научно-исследовательский онкологический институт им. П.А.Герцена Минздрава РФ15092013153VOL 15, NO3 (2013)ТОМ 15, №3 (2013)495409042020Copyright ©; 2013, Consilium MedicumCopyright ©; 2013, ООО "Консилиум Медикум"2013Consilium MedicumООО "Консилиум Медикум"https://creativecommons.org/licenses/by-nc/4.0https://modernonco.orscience.ru/1815-1434/article/view/26912

С позиций современных знаний о роли мутаций определенных генов и связанной с этим эффективностью лекарственной терапии необходимо проведение генетических исследований для рационального выбора 1-й линии лечения. Применение ингибиторов тирозинкиназы у больных с наличием мутации EGFR в 1-й линии терапии больных немелкоклеточным раком легкого позволяет добиться достоверного увеличения медианы до прогрессирования заболевания при меньшей токсичности проводимого лечения у грамотно отобранной когорты больных.

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