Journal of Modern OncologyJournal of Modern OncologyСовременная онкология1815-14341815-1442LLC Obyedinennaya Redaktsiya26897ArticlesСтатьиResearch ArticleBevatsizumab v kombinatsii s khimioluchevoy terapiey u bol'nykh glioblastomoyБевацизумаб в комбинации с химиолучевой терапией у больных глиобластомойSmolinAleksey VladimirovichСмолинАлексей Владимирович

нач. Радиологического центра

KonevAndrey VladimirovichКоневАндрей Владимирович

зав. 31-м радиологическим (терапевтическим) отд-нием

KobyakovGrigoriy L'vovichКобяковГригорий Львович

рук. группы химиотерапии опухолей ЦНС 7-го отд-ния

NikolaevaSvetlana NikolaevnaНиколаеваСветлана Николаевна

врач-радиолог 31-го радиологического (терапевтического) отд-ния

ShamanskayaYuliya Evgen'evnaШаманскаяЮлия Евгеньевна

врач-радиолог 31-го радиологического (терапевтического) отд-ния

GorbunovAleksey Valer'evichГорбуновАлексей Валерьевич

врач отд-ния МРТ

ФГКУ Главный военный клинический госпиталь им. акад. Н.Н.Бурденко Минобороны РоссииНИИ нейрохирургии им. Н.Н.Бурденко РАМН15092013153VOL 15, NO3 (2013)ТОМ 15, №3 (2013)162309042020Copyright ©; 2013, Consilium MedicumCopyright ©; 2013, ООО "Консилиум Медикум"2013Consilium MedicumООО "Консилиум Медикум"https://creativecommons.org/licenses/by-nc/4.0https://modernonco.orscience.ru/1815-1434/article/view/26897

Представлен обзор литературы по клиническим исследованиям II и III фазы, изучавшим эффективность и безопасность использования бевацизумаба в комбинации с химиолучевой терапией у больных с впервые диагностированной глиобластомой головного мозга. Приведены данные о статистически значимом увеличении выживаемости без прогрессирования у больных глиобластомой на 4,4 мес и снижении относительного риска прогрессирования или смерти на 36% при применении бевацизумаба в комбинации со стандартной химиолучевой терапией у больных с вновь диагностированной глиобластомой. Показано, что добавление бевацизумаба достоверно увеличивает время до ухудшения статуса Карновского, статуса общего здоровья, физического, социального функционирования, моторного и коммуникационного дефицита. Оценена безопасность применения бевацизумаба в комбинации с химиолучевой терапией. Освещены возможные показания к применению бевацизумаба в 1-й линии терапии, приведены данные собственного опыта применения бевацизумаба по этим показаниям.

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