Journal of Modern OncologyJournal of Modern Oncology1815-14341815-1442LLC Obyedinennaya Redaktsiya26784Research ArticleKlinicheskiy sluchay effektivnogo lecheniya lapatinibom (Tayverb)i kapetsitabinom (Kseloda) bol'noy disseminirovannym rakom molochnoy zhelezy s giperekspressiey ErbB2 (Her-2/neu) s metastaticheskim porazheniem veshchestva i obolochek golovnogo mozgaNaskhletashviliD R-ChmutinG E-15092009113424409042020Copyright © 2009, Consilium Medicum2009рак молочной железыметастатическое поражение головного мозгахимиотерапиякапецитабин[Chang E, Lob S. Diagnosis and Management of Central Nervous System Metastases from Breast Cancer. The Oncologist 2003; 8 (5): 398–410.][Bendell J.C., Domchek S.M., Burstein H.J. et al. Central nervous system metastases in women who receive trastuzumab - based therapy for metastatic breast carcinoma. Cancer 2003; 97: 2972–7.][Burstein H.J., Lieberman G, Slamon D.J. et al. Isolated central nervous system metastases in patients with HER2-overexpressing advanced breast cancer treated with first - line trastuzumab - based therapy. Ann Oncol 2005; 16: 1772–7.][De la Monte S.M., Hutchins G.M., Moore G.W. Estrogen and progesterone receptors in prediction of metastatic behavior of breast carcinoma. Am J Med 1984; 76: 11–7.][Heinrich B, Brudler O, Siekiera W et al. Development of brain metastasis in metastatic breast cancer responding to treatment with trastuzumab. Proc Am Soc Clin Oncol 2003; 22: 37 (abstr 147).][Lin N.U., Bellon J.R., Winer E.P. CNS metastases in breast cancer. J Clin Oncol 2004; 22: 3608–17.][Wardley A.M., Danson S, Clayton A.J. et al. High incidence of brain metastases in patients treated with trastuzumab for metastatic breast cancer at a large cancer center. Proc Am Soc Clin Oncol 2002; 21: 61a (abstr 241).][Samaan N.A., Buzdar A.U., Aldinger K.A. et al. Estrogen receptor: A prognostic factor in breast cancer. Cancer 1981; 47: 554–60.][Weitzen R, Zach L, Kaufman B et al. High incidence of brain metastasis in patients on trastuzumab for advanced breast cancer. Proc Am Soc Clin Oncol 2002; 21: 316 (abstr 1936).][Bezjak A, Adam J, Barton R et al. Symptom response after palliative radiotherapy for patients with brain metastases. Eur J Cancer 2002; 38: 487–96.][Khuntia D, Brown P, Li J et al. Whole - brain radiotherapy in the management of brain metastasis. J Clin Oncol 2006; 24: 1295–304.][Tsao M.N., Lloyd N, Wong R et al. Whole brain radiotherapy for the treatment of multiple brain metastases. Cochrane Database Syst Rev 2006; 3: CD003869.][Fabi A, Vidiri A, Ferretti G et al. Dramatic regression of multiple brain metastases from breast cancer with capecitabine: Another arrow at the bow? Cancer Invest 2006; 24: 466–8.][Hikino H, Yamada T, Johbara K et al. Potential role of chemoradiation with oral capecitabine in a breast cancer patient with central nervous system relapse. Breast 2006; 15: 97–9.][Siegelmann-Danieli N, Stein M, Bar-Ziv J. Complete response of brain metastases originating in breast cancer to capecitabine therapy. Isr Med Assoc J 2003; 5: 833–4.][Wang M.L., Yung W.K., Royce M.E. et al. Capecitabine for 5-fluorouracil - resistant brain metastases from breast cancer. Am J Clin Oncol 2001; 24: 421–4.][Lin N.U., Carey L.A., Liu M.C. et al. Phase II trial of lapatinib for brain metastases in patients with HER2+ breast cancer. J Clin Oncol 2006; 24 (suppl. 18): 503a.]