Journal of Modern OncologyJournal of Modern OncologyСовременная онкология1815-14341815-1442LLC Obyedinennaya Redaktsiya26717ArticlesСтатьиResearch ArticleOpyt primeneniya preparata Eloksatin pri kolorektal'nom rakeОпыт применения препарата Элоксатин при колоректальном ракеVoznyyE KВозныйЭ КPopovA YuПоповА ЮAstrakhankinaT AАстраханкинаТ АGrishunenkovaE PГришуненковаЕ ПPolyanskayaE VПолянскаяЕ ВГородская клиническая больница №57, Москва15062008102NO2 (2008)ТОМ 10, №2 (2008)485209042020Copyright ©; 2008, Consilium MedicumCopyright ©; 2008, ООО "Консилиум Медикум"2008Consilium MedicumООО "Консилиум Медикум"https://creativecommons.org/licenses/by-nc/4.0https://modernonco.orscience.ru/1815-1434/article/view/26717

Препараты платины (цисплатин и карбоплатин) прекрасно зарекомендовали себя в химиотерапии различных солидных опухолей. Однако их применение достаточно часто требует поддерживающей терапии, включающей в себя противорвотные препараты, большой объем инфузионной терапии, колониестимулирующие факторы и др. Цисплатин и карбоплатин имеют ограничения в применения в связи с выраженными побочными эффектами, такими как высокая эметогенность, нефротоксичность, высокая кумулятивная нейротоксичность, гематологическая токсичность, ототоксичность. В последние годы в практику вошел препарат третьего поколения производного платины – Элоксатин® (оксалиплатин, “Санофи-Авентис”, Франция), который стал повсеместно применяться в лечении различных злокачественных новообразований. Привлекательным для практикующих врачей-онкологов является отсутствие у Элоксатина нефро - и ототоксичности.

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