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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Journal of Modern Oncology</journal-id><journal-title-group><journal-title xml:lang="en">Journal of Modern Oncology</journal-title><trans-title-group xml:lang="ru"><trans-title>Современная онкология</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1815-1434</issn><issn publication-format="electronic">1815-1442</issn><publisher><publisher-name xml:lang="en">LLC Obyedinennaya Redaktsiya</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">26609</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Sovremennye vozmozhnosti lecheniya kolorektal'nogo raka</article-title><trans-title-group xml:lang="ru"><trans-title>Современные возможности лечения колоректального рака</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Barsukov</surname><given-names>Yu A</given-names></name><name xml:lang="ru"><surname>Барсуков</surname><given-names>Ю А</given-names></name></name-alternatives><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Knysh</surname><given-names>V I</given-names></name><name xml:lang="ru"><surname>Кныш</surname><given-names>В И</given-names></name></name-alternatives><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en"></institution></aff><aff><institution xml:lang="ru">НИИ КО ГУ РОНЦ РАМН им. Н.Н.Блохина, Москва</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2006-06-15" publication-format="electronic"><day>15</day><month>06</month><year>2006</year></pub-date><volume>8</volume><issue>2</issue><issue-title xml:lang="en">VOL 8, NO2 (2006)</issue-title><issue-title xml:lang="ru">ТОМ 8, №2 (2006)</issue-title><fpage>7</fpage><lpage>16</lpage><history><date date-type="received" iso-8601-date="2020-04-09"><day>09</day><month>04</month><year>2020</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2006, Consilium Medicum</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2006, ООО "Консилиум Медикум"</copyright-statement><copyright-year>2006</copyright-year><copyright-holder xml:lang="en">Consilium Medicum</copyright-holder><copyright-holder xml:lang="ru">ООО "Консилиум Медикум"</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://modernonco.orscience.ru/1815-1434/article/view/26609">https://modernonco.orscience.ru/1815-1434/article/view/26609</self-uri><abstract xml:lang="ru"><p>В структуре онкологической заболеваемости колоректальный рак КРР прочно занимает второе-третье место в большинстве экономически развитых стран мира как у мужчин, так и у женщин. За последние 20 лет рак толстой кишки переместился в структуре онкологической заболеваемости населения Российской Федерации с 6-го на 3-е место. В связи с этим ознакомление врачей общего профиля с клинической картиной КРР и методами диагностики приобретает особую актуальность, тем более что контингент больных раком толстой кишки, состоящий на учете в онкологических учреждениях, увеличился более чем в два раза.</p></abstract><kwd-group xml:lang="ru"><kwd>новообразование</kwd><kwd>колоректальный рак</kwd><kwd>диагностика</kwd><kwd>химиотерапия</kwd><kwd>метастазы</kwd><kwd>Кселода</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Vogel I, Soeth E, Ruder C et al. Disseminated tumor cells in the blood and/or bone marrow of patients with colorectal carcinoma are an independent prognostic factor. Ann. Oncol., 2000; 11 (suppl. 4): 43, abstr. 183.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Efficacy of adjuvant fluorouracil and folinic acid in colon cancer. International Multicentre Pooled Analysis of Colon Cancer Trials (IMPACT) investigators. Lancet, 1995 Apr 15;345(8955):939-44.</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Haller D, Catalano P.J, Macdonald J.S, Mayer R.J. Fluorouracil (FU), leucovorin (LV) and levamisole (LEV) adjuvant therapy for colon cancer: five - year final report of int-0089. Proc Am Soc Clin Oncol 1998; 17: 256a (Abstr 982).</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Wolmark N, Rockette H, Mamounas E et al. Clinical trial to assess the relative efficacy of fluorouracil and leucovorin, fluorouracil and levamisole in patients with Dukes’ B and C carcinoma of the colon: results from National Surgical Adjuvant Breast and Bowel Project C-04. J Clin Oncol. 1999; 17: 3553-9.</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>Andre T et al. Semimonthly versus monthly regimen of fluorouracil and leucovorin administered for 24 or 36 weeks as adjuvant therapy in stage II and III colon cancer: results of a randomized trial. J Clin Oncol, 2003 Aug 1;21(15):2896-903.</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>Grothey A et al. Deficits in management of patients with colorectal carcinoma in Germany. Results of multicenter documentation of therapy algorithms. Med Klin, 2002 May 15;97(5):270-7.</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>S. Hensley Alford et al. Stage III colon cancer in the elderly: Adjuvant therapy and survival. Proc Am Soc Clin Oncol 2003 abstr 3008.</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>Van Cutsem E, Twelves C, Cassidy J et al. Oral capecitabine compared with intravenous fluorouracil plus leucovorin in patients with metastatic colorectal cancer: results of a large phase III study. J Clin Oncol 2001;19:4097-106.</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>Hoff P.M, Ansari R, Batist G et al. Comparison of oral capecitabine versus intravenous fluorouracil plus leucovorin as first - line treatment in 605 patients with metastatic colorectal cancer: results of a randomized phase III study. J Clin Oncol 2001;19:2282-92.</mixed-citation></ref><ref id="B10"><label>10.</label><mixed-citation>Cassidy J. et al. Capecitabine (X) vs bolus 5-FU/leucovorin (LV) as adjuvant therapy for colon cancer (the X-ACT study): efficacy results of a phase III trial. Proceedings ASCO 2004 abstract 3509.</mixed-citation></ref><ref id="B11"><label>11.</label><mixed-citation>Twelves C. et al. Capecitabine as adjuvant treatment for satge III colon cancer. N Engl J Med 2005; 352:269-704.</mixed-citation></ref><ref id="B12"><label>12.</label><mixed-citation>Joseph N.E et al. Accuracy of determining nodal negativity in colorectal cancer on the basis of the number of nodes retrieved on resection. Ann Surg Oncol. 2003 Apr;10(3):213-8.</mixed-citation></ref><ref id="B13"><label>13.</label><mixed-citation>Scheithauer W. et al. Oral capecitabine as an alternative to i.v. 5-fluorouracil - based adjuvant therapy for colon cancer: safety results of a randomized, phase III trial Annals of Oncology 14: 1735-1743, 2003.</mixed-citation></ref></ref-list></back></article>
