Journal of Modern OncologyJournal of Modern Oncology1815-14341815-1442LLC Obyedinennaya Redaktsiya10134010.26442/18151434.2022.3.201777Research ArticleThe surgical treatment of locally advanced angiosarcoma of the anterior mediastinum. A clinical caseNovikovDmitriy V.<p>Cand. Sci. (Med.)</p>dima-dima.000@mail.ruhttps://orcid.org/0000-0001-6544-5674ChekiniAntonio K.<p>Cand. Sci. (Med.)</p>docpro13@gmail.comAvturkhanovTimur M.<p>Intern</p>timuravt@mail.ruMkrtumyanRadik A.<p>Thoracic Surgeon</p>r.mkrtumyan@mail.ruRussian Railways-Medicine Central Clinical Hospital2511202224333633921022022Copyright © 2022, Consilium Medicum2022<p>Tumors of the mediastinum is a collective term that includes neoplasms of various degrees of malignancy, different morphogenesis, originating from heterogeneous tissues and combined into one nosological form according to anatomical localization. Angiosarcoma is a rare malignant tumor originating from a vessel wall. In the general structure of sarcomas, its frequency is estimated at 1%. The tumor is characterized by an aggressive course, local recurrence, hematogenous metastasis, poor sensitivity to chemotherapy and radiotherapy. Surgery remains the main treatment for angiosarcomas. The article presents a clinical case. A 55-year-old patient has multiple primary malignant neoplasms: cancer of the body of the uterus pT1aN0M0 IA stage. Surgical treatment from 12.15.2020 panhysterectomy; angiosarcoma of the anterior mediastinum with lesions of the manubrium, body of the sternum and the 1st rib on the left, invasion into the left brachiocephalic vein with the formation of a tumor thrombus in it, growing into the upper lobe of the left lung, T3N0M0, G1. Surgical treatment from 08.12.2021 resection of the manubrium and body of the sternum with resection of the anterior segments I, II, III ribs on both sides, resection of the left brachiocephalic vein, removal of an anterior mediastinal tumor, atypical resection of the upper lobe of the left lung en bloc, reconstruction of the sternum and ribs with an individual titanium 3D prosthesis. The patient was discharged from the hospital in a satisfactory condition.</p>angiosarcomamediastinal tumorsprimary multiple malignant neoplasms3D prostheticsангиосаркомаопухоли средостенияпервично-множественные злокачественные новообразования3D-протезирование[Барболина Т. Д., Бычков М.Б., Аллахвердиев А.К., и др. Практические рекомендации по лекарственному лечению опухолей вилочковой железы (тимомы и рака тимуса). Злокачественные опухоли. 2020;10(3s2-1):603-14 [Barbolina TD, Bychkov MB, Allakhverdiev AK, et al. Prakticheskie rekomendatsii po lekarstvennomu lecheniiu opukholei vilochkovoi zhelezy (timomy i raka timusa). Zlokachestvennye opukholi. 2020;10(3s2-1):603-14 (in Russian)]. DOI:10.18027 / 2224-5057-2020-10-3s2-35][Chaudhry IUH. Radical surgical resection of giant Angiosarcoma of the posterior Mediastinum: A rare neoplasm with rare presentation as epigastric pain. Ann Med Surg (Lond). 2021;72:103087. DOI:10.1016/j.amsu.2021.103087][Zhi Q, Ma Z, Lin G, et al. Long-Term Observation and Treatment of Epithelioid Haemangioendothelioma of the Mediastinum: A Case Report. Front Surg. 2021;8:678572. DOI:10.3389/fsurg.2021.678572][Tan YB, Yu XF, Fan JQ, Li JF. Angiosarcoma originating in the anterior mediastinum: A case report. Medicine (Baltimore). 2018;97(50):e13459. DOI:10.1097/MD.0000000000013459][Vats K, Al-Nourhji O, Wang H, Wang C. Primary epithelioid angiosarcoma of the mediastinum, cytomorphologic features of a rare entity-A case report and literature review. Diagn Cytopathol. 2022;50(7):E181-7. DOI:10.1002/ dc.24946][Paral K, Krausz T. Vascular tumors of the mediastinum. Mediastinum. 2020;4:25. DOI:10.21037/med-20-40][Datta D, Gerardi DA, Lahiri B. Mediastinal angiosarcoma presenting as diffuse alveolar hemorrhage. Respir Med Case Rep. 2018;23:115-7. DOI:0.1016/j.rmcr.2018.01.005][Пикин О.В., Глушко В.А., Багров В.А., и др. Гемангиоэндотелиома правой плечеголовной вены. Хирургия. Журнал им. Н.И. Пирогова. 2022;4:96-100 [Pikin OV, Glushko VA, Bagrov VA. Hemangioendothelioma of the right innominate vein. Khirurgiia. Zhurnal im. N.I. Pirogova. 2022;4:96-100 (in Russian)]. DOI:10.17116/hirurgia202204196][Xiang Y, Yan L, Lin X. Posterior Mediastinal Epithelioid Angiosarcoma Arising in Schwannoma: A Case Report and Review of the Literature. Front Surg. 2021;8:666389. DOI:10.3389/fsurg.2021.666389][Феденко А.А., Бохян А.Ю., Горбунова В.А., и др. Практические рекомендации по лекарственному лечению сарком мягких тканей. Злокачественные опухоли. 2021;11(3s2-1):277-86 [Fedenko AA, Bokhian AIu, Gorbunova VA, et al. Prakticheskie rekomendatsii po lekarstvennomu lecheniiu sarkom miagkikh tkanei. Zlokachestvennye opukholi. 2021;11(3s2-1):277-86 (in Russian)]. DOI:10.18027/2224-5057-2021-11-3s2–18]